2-Iodoestradiol
2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10(9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serum albumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research.
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- CAS No.: 24381-12-2
- Formule: C18H23IO2
- Masse moléculaire:398.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | GI50 |
6.9 μM
Compound: 14
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Cytotoxicity against prostate DU-145 cancer cell lines.
Cytotoxicity against prostate DU-145 cancer cell lines.
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[PMID: 7783135] |
| HCT-116 | GI50 |
5 μM
Compound: 14
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Cytotoxicity against colon HCT116 cancer cell lines.
Cytotoxicity against colon HCT116 cancer cell lines.
|
[PMID: 7783135] |
| HOP-62 | GI50 |
4.2 μM
Compound: 14
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Cytotoxicity against lung HOP-62 cancer cell lines.
Cytotoxicity against lung HOP-62 cancer cell lines.
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[PMID: 7783135] |
| MDA-MB-435 | GI50 |
2.1 μM
Compound: 14
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Cytotoxicity against breast MDA-MB-435 cancer cell lines.
Cytotoxicity against breast MDA-MB-435 cancer cell lines.
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[PMID: 7783135] |
| OVCAR-3 | GI50 |
3.5 μM
Compound: 14
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Cytotoxicity against ovarian OVCAR-3 cancer cell lines.
Cytotoxicity against ovarian OVCAR-3 cancer cell lines.
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[PMID: 7783135] |
| Panel (Carcinoma cell lines) | GI50 |
5.5 μM
Compound: 14
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Mean graph midpoint for all human cancer cell line cytotoxicity.
Mean graph midpoint for all human cancer cell line cytotoxicity.
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[PMID: 7783135] |
| SF-539 | GI50 |
3 μM
Compound: 14
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Cytotoxicity against CNS SF-539 cancer cell lines.
Cytotoxicity against CNS SF-539 cancer cell lines.
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[PMID: 7783135] |
| SN12C | GI50 |
6.6 μM
Compound: 14
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Cytotoxicity against renal SN12C cancer cell lines.
Cytotoxicity against renal SN12C cancer cell lines.
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[PMID: 7783135] |
| UACC-62 | GI50 |
3.6 μM
Compound: 14
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Cytotoxicity against melanoma UACC-62 cancer cell lines.
Cytotoxicity against melanoma UACC-62 cancer cell lines.
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[PMID: 7783135] |
Chemical Information
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CAS No. 24381-12-2
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Masse moléculaire 398.28
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Formule C18H23IO2
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SMILES
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(I)=C(O)C=C4CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Iodoestradiol Related Classifications
HY-118124 Related Classifications
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