4-Chlorochalcone
Based on 1 Customer Validation
4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC50 = 0.082 μM, hMAO-A: IC50 = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC50 = 2.79 μM). 4-Chlorochalcone is a chalcone derivative.
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- CAS No.: 956-04-7
- Formule: C15H11ClO
- Masse moléculaire:242.70
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAL-51 | GI50 |
5.85 μM
Compound: SSE14105
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Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay
Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay
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[PMID: 28743509] |
| HCT-116 | GI50 |
16.54 μM
Compound: SSE14105
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Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay
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[PMID: 28743509] |
| HepG2 | IC50 |
97.2 μM
Compound: 2
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Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 22658085] |
| Neutrophil | IC50 |
5.3 μM
Compound: 2
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| Neutrophil | IC50 |
5.4 μM
Compound: 2
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| RBL-1 | IC50 |
85 μM
Compound: 20
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Inhibition of 5-lipoxygenase in rat RBL1 cells
Inhibition of 5-lipoxygenase in rat RBL1 cells
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10.1007/s00044-013-0745-7 |
Chemical Information
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CAS No. 956-04-7
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Appearance Solid
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Masse moléculaire 242.70
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Formule C15H11ClO
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Color Off-white to light yellow
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SMILES
O=C(C=CC1=CC=C(Cl)C=C1)C=2C=CC=CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
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Fiche technique (265 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Chlorochalcone Related Classifications
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