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Alnuctamab

(Synonyms: EM901; CC-93269)
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Based on 1 Customer Validation

Alnuctamab (EM901) is a bispecific T-cell engager targeting BCMA and CD3, belonging to an asymmetric two-armed humanized IgG1 antibody. Alnuctamab can simultaneously bind to BCMA expressed on the surface of myeloma cells and CD3 molecules on the surface of T cells, recruiting T cells to kill tumors. Alnuctamab is used for the research of multiple myeloma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

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  • Pureté: 99.89%
  • CAS No.: 2296827-07-9
  • Masse moléculaire:192.13 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Alnuctamab
  • Experimental Validation Results for Alnuctamab
  • Experimental Validation Results for Alnuctamab
  • Experimental Validation Results for Alnuctamab
  • Alnuctamab Chemical Structure
    Alnuctamab Chemical Structure
CAS No.: 2296827-07-9
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Alnuctamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa/lambda with domain crossover, trivalent

  • 1/16

    Immobilized CD3 epsilon/CD3e Protein can bind Alnuctamab. The EC50 for this effect is 0.728 ng/mL.

  • 1/16

    Immobilized BCMA/TNFRSF17 Protein, Human can bind Alnuctamab. The EC50 for this effect is 0.051 ng/mL.

  • 1/16

    Flow Cytometry analysis of K562 cells labelling BCMA (red) with Alnuctamab (HY-P99430). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 11,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Alnuctamab Chemical Structure
    1/16
  • Alnuctamab
  • Immobilized CD3 epsilon/CD3e Protein can bind Alnuctamab. The EC50 for this effect is 0.728 ng/mL.
  • Immobilized BCMA/TNFRSF17 Protein, Human can bind Alnuctamab. The EC50 for this effect is 0.051 ng/mL.
  • Flow Cytometry analysis of K562 cells labelling BCMA (red) with Alnuctamab (HY-P99430). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 11,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa/lambda with domain crossover, trivalent