Am-KYa12K4
Am-KYa12K4 is a peptide-ionizable lipid (PIL) that can be incorporated into lipid nanoparticles (LNPs) to deliver mRNA to the thymus with high specificity. LNPs formulated with Am-KYa12K4 significantly enhance mRNA expression in the thymus.
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- Formule: C134H262N12O7
- Masse moléculaire:2153.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Am-KYa12K4 LNPs combined with 126ts-Luc mRNA (1.0 mg/kg; i.v.; single dose) achieve enhanced thymus-selective mRNA delivery with 82.4% organ specificity in healthy female C57BL/6 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 6-8 weeks old, 18-20 g)[1]
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Dosage:0.3 mg/kg Luc mRNA
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Administration:i.v.; single dose
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Result:Mediated luciferase expression with 66.4% specificity in the thymus, with reduced expression in all other evaluated organs.
Reached thymus radiance of ~1×106 photons s-1 cm-2 sr-1, which was significantly higher than radiance in the heart, liver, lungs, spleen, and kidneys.
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Animal Model:C57BL/6 (female, 6-8 weeks old, 18-20 g)[1]
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Dosage:1.0 mg/kg 126ts-Luc mRNA
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Administration:i.v.; single dose
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Result:Mediated luciferase expression with 82.4% specificity in the thymus, with minimal expression in other organs.
Reached thymus radiance of ~3.5×105 photons s-1 cm-2 sr-1, which was significantly higher than radiance in all other evaluated organs.
Chemical Information
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Masse moléculaire 2153.59
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Formule C134H262N12O7
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SMILES
N[C@@H](CCCCN)C(N[C@@H](C1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N[C@@H](CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N[C@@H](CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N)=O)=O)=O)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Am-KYa12K4 Related Classifications
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