BAY-4931
Based on 1 publication(s) in Google Scholar
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM.
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- Pureté: 98.72%
- CAS No.: 423150-91-8
- Formule: C22H16ClN3O4
- Masse moléculaire:421.83
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BAY-4931
More
Activité biologique
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PPAR-γ 0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay) |
mouse PPARγ 0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) |
hPPARγ 0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) |
BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM[1].
BAY-4931 only inhibits CYP2C8 in CYP inhibition test[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:UM-UC-9 cells
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Concentration:0-10 μM
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Incubation Time:7 days
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Result:Inhibited proliferation with an IC50 of 3.4 nM.
Chemical Information
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CAS No. 423150-91-8
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Appearance Solid
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Masse moléculaire 421.83
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Formule C22H16ClN3O4
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Color Light yellow to light brown
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SMILES
O=C(NC1=CC=C(OC(C2=CC=C(CC)C=C2)=N3)C3=C1)C4=CC([N+]([O-])=O)=CC=C4Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909. [Abstract]2025 May 8:2025.05.04.651770. PMID: 40654962
Solvant et solubilité
DMSO : 125 mg/mL (296.33 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3706 mL | 11.8531 mL | 23.7062 mL | 59.2656 mL |
| 5 mM | 0.4741 mL | 2.3706 mL | 4.7412 mL | 11.8531 mL | |
| 10 mM | 0.2371 mL | 1.1853 mL | 2.3706 mL | 5.9266 mL | |
| 15 mM | 0.1580 mL | 0.7902 mL | 1.5804 mL | 3.9510 mL | |
| 20 mM | 0.1185 mL | 0.5927 mL | 1.1853 mL | 2.9633 mL | |
| 25 mM | 0.0948 mL | 0.4741 mL | 0.9482 mL | 2.3706 mL | |
| 30 mM | 0.0790 mL | 0.3951 mL | 0.7902 mL | 1.9755 mL | |
| 40 mM | 0.0593 mL | 0.2963 mL | 0.5927 mL | 1.4816 mL | |
| 50 mM | 0.0474 mL | 0.2371 mL | 0.4741 mL | 1.1853 mL | |
| 60 mM | 0.0395 mL | 0.1976 mL | 0.3951 mL | 0.9878 mL | |
| 80 mM | 0.0296 mL | 0.1482 mL | 0.2963 mL | 0.7408 mL | |
| 100 mM | 0.0237 mL | 0.1185 mL | 0.2371 mL | 0.5927 mL |
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