Mmp14 - matrix metallopeptidase 14 (membrane-inserted) Gene

Also Known as sabe; MMP-X1; MT1-MMP; MT-MMP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17387

About Mmp14

Chromosome 14: 54,669,069-54,682,821 forward strand.GRCm39:CM001007.3

This gene has 7 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 113 phenotypes. Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 1.7) and 24 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]

Mmp14 Products (1)

mRNA Protein Name
NM_008608.4 NP_032634.3 matrix metalloproteinase-14 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
21572390 MGI
enables metalloendopeptidase activity IMP
IMP: Inferred from mutant phenotype
10737763 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
15572153 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
15572153 MGI
acts upstream of or within chondrocyte proliferation IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within collagen catabolic process IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within craniofacial suture morphogenesis IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within endochondral ossification IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within head development IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
15572153 MGI
involved in negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
21572390 MGI
acts upstream of or within ossification IGI
IGI: Inferred from genetic interaction
18022611 MGI
involved in positive regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
21572390 MGI
involved in positive regulation of macrophage migration IMP
IMP: Inferred from mutant phenotype
24990232 MGI
involved in positive regulation of myotube differentiation IMP
IMP: Inferred from mutant phenotype
21572390 MGI
involved in skeletal system development IMP
IMP: Inferred from mutant phenotype
10737763 MGI
acts upstream of or within zymogen activation IMP
IMP: Inferred from mutant phenotype
15572153 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp14 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (35 - 87)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 283)

HX

HX: cd00094 (315 - 507)

DUF3377

DUF3377: cl13321 (559 - 581)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-14

  • Membrane type 1-MMP

  • matrix metalloproteinase 14 (membrane-inserted)

  • membrane-type-1 matrix metalloproteinase

  • type 1 matrix metalloprotease 14

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-12169 Marimastat Inhibitor 99.81% Phase 3
Inhibitory Antibodies (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P990045 Lixudebart Inhibitor 98.88% Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-15827 NSC 405020 Inhibitor 99.63% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-124373 ND-336 Inhibitor 97.16% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-114785 BPHA Inhibitor 99.88% Unkown
HY-RS08528 MMP14 Human Pre-designed siRNA Set A / Unkown
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 Substrate 96.30% Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-160720 ASPH-IN-1 Inhibitor / Unkown
HY-P3120A Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA Substrate / Unkown
HY-RS08529 Mmp14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08530 Mmp14 Rat Pre-designed siRNA Set A / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
Inhibitory Antibodies (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P991316 KD014 96.98% Unkown
HY-P991478 RLVT-14-02 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp14 NCBI NCBI:4323