EIF2S1 - eukaryotic translation initiation factor 2 subunit alpha Gene
Also Known as EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha
Species: Homo sapiens
About EIF2S1
This gene has 6 transcripts (splice variants) and 238 orthologues. Ubiquitous expression in testis (RPKM 19.0), esophagus (RPKM 15.6) and 25 other tissues.
Summary
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
EIF2S1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004094.5 | NP_004085.1 | eukaryotic translation initiation factor 2 subunit 1 |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9431994 | GOA |
| enables ribosome binding |
IDA
IDA: Inferred from direct assay
|
17894550 | GOA |
| enables translation initiation factor activity |
IDA
IDA: Inferred from direct assay
|
16289705 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in HRI-mediated signaling |
IDA
IDA: Inferred from direct assay
|
32132706 | GOA |
| involved in PERK-mediated unfolded protein response |
IDA
IDA: Inferred from direct assay
|
33384352 | GOA |
| involved in mitophagy |
IDA
IDA: Inferred from direct assay
|
38340717 | GOA |
| involved in regulation of translation in response to endoplasmic reticulum stress |
IMP
IMP: Inferred from mutant phenotype
|
18508033 | GOA |
| involved in response to endoplasmic reticulum stress |
IDA
IDA: Inferred from direct assay
|
33384352 | GOA |
| involved in response to endoplasmic reticulum stress |
IMP
IMP: Inferred from mutant phenotype
|
18508033 | GOA |
| involved in translational initiation |
IDA
IDA: Inferred from direct assay
|
16289705 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| part of eukaryotic translation initiation factor 2 complex |
IDA
IDA: Inferred from direct assay
|
23063529 | GOA |
| part of eukaryotic translation initiation factor 2 complex |
IPI
IPI: Inferred from physical interaction
|
31836389 | GOA |
| is active in mitochondrion |
IDA
IDA: Inferred from direct assay
|
38340717 | GOA |
EIF2S1 Protein Structure
S1: S1 RNA binding domain (14 - 88)
EIF_2_alpha: Eukaryotic translation initiation factor 2 alpha subunit (130 - 243)
- 0
- 100
- 200
- 300
- 315 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
eukaryotic translation initiation factor 2 subunit 1 |
|
EIF2S1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
EIF2S1 | P05198 | EIF2S3 | Homo sapiens | P41091 | 33961781 | |
|
Intra
|
EIF2S1 | P05198 | EIF2S3 | Homo sapiens | P41091 | 16288713 | |
|
Intra
|
EIF2S1 | P05198 | EIF2S3 | Homo sapiens | P41091 | 37507029 | |
|
Cross
|
EIF2S1 | P05198 | Eif2ak3 | Mus musculus | Q9Z2B5 | 16288713 | |
|
Cross
|
EIF2S1 | P05198 | Eif2ak3 | Mus musculus | Q9Z2B5 | 16288713 | |
|
Intra
|
EIF2S1 | P05198 | VAC14 | Homo sapiens | Q08AM6 | 32296183 | |
|
Intra
|
EIF2S1 | P05198 | VAC14 | Homo sapiens | Q08AM6 | 32296183 | |
|
Intra
|
EIF2S1 | P05198 | VAC14 | Homo sapiens | Q08AM6 | 32296183 | |
|
Intra
|
EIF2S1 | P05198 | PRMT7 | Homo sapiens | Q9NVM4 | 32296183 | |
|
Intra
|
EIF2S1 | P05198 | PRMT7 | Homo sapiens | Q9NVM4 | 33961781 | |
|
Intra
|
EIF2S1 | P05198 | ACTN1 | Homo sapiens | P12814 | 32296183 | |
|
Intra
|
EIF2S1 | P05198 | EIF2AK2 | Homo sapiens | P19525 | 16288713 | |
|
Intra
|
EIF2S1 | P05198 | EIF2S2 | Homo sapiens | P20042 | 16932749 | |
|
Intra
|
EIF2S1 | P05198 | EIF2S2 | Homo sapiens | P20042 | 16288713 |
EIF2S1 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80811 | Phospho-EIF2S1 (Ser51) Antibody (YA203) | WB | Human, Mouse, Rat |
| HY-P80811A | Phospho-EIF2S1 (Ser51) Antibody (YA203)(PBS only) | WB | Human, Mouse, Rat |
| HY-P83763 | EIF2S1 Antibody(YA3562) | WB, ICC/IF, IHC-P, FC, IP | Human, Mouse, Rat, Monkey |
| HY-P85616 | EIF2S1 Antibody (YA5308) | WB, ICC/IF, IP | Human, Mouse, Rat |
| HY-P86063 | Phospho-EIF2S1(Ser51) Antibody (YA5755) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86419 | EIF2S1 Antibody (YA6111) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Vaccinia |
|
|
| Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus |
|
|
| Fatty Liver Disease |
|
|
| Cowpox |
|
|
| Rift Valley Fever |
|
|
| Newcastle Disease |
|
|
| Liver Disease |
|
|
| Influenza |
|
|
| Yellow Fever |
|
|
| Leukoencephalopathy With Vanishing White Matter |
|
|
| Mehmo Syndrome |
|
|
| Viral Infectious Disease |
|
|
| Dystonia 16 |
|
|
| Beta-Thalassemia |
|
|
| Melanoma In Congenital Melanocytic Nevus |
|
|
| Retinal Degeneration |
|
|
| Dystonia |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | EIF2S1 | VGNC | VGNC:28390 |
| Canis familiaris | EIF2S1 | VGNC | VGNC:40266 |
| Mus musculus | EIF2S1 | MGD | MGI:95299 |
| Macaca mulatta | EIF2S1 | VGNC | VGNC:72187 |
| Felis catus | EIF2S1 | VGNC | VGNC:61778 |
| Rattus norvegicus | EIF2S1 | RGD | RGD:620963 |
| Others | EIF2S1 | NCBI |