EIF2S1 - eukaryotic translation initiation factor 2 subunit alpha Gene

Also Known as EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1965

About EIF2S1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:67,360,328-67,386,516 (from NCBI)

This gene has 6 transcripts (splice variants) and 238 orthologues. Ubiquitous expression in testis (RPKM 19.0), esophagus (RPKM 15.6) and 25 other tissues.

Summary

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

EIF2S1 Products (1)

mRNA Protein Name
NM_004094.5 NP_004085.1 eukaryotic translation initiation factor 2 subunit 1
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
9431994 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
17894550 GOA
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
16289705 GOA
Biological Process GO Annotation Evidence Références Source
involved in HRI-mediated signaling IDA
IDA: Inferred from direct assay
32132706 GOA
involved in PERK-mediated unfolded protein response IDA
IDA: Inferred from direct assay
33384352 GOA
involved in mitophagy IDA
IDA: Inferred from direct assay
38340717 GOA
involved in regulation of translation in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
18508033 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
33384352 GOA
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
18508033 GOA
involved in translational initiation IDA
IDA: Inferred from direct assay
16289705 GOA
Cellular Component GO Annotation Evidence Références Source
part of eukaryotic translation initiation factor 2 complex IDA
IDA: Inferred from direct assay
23063529 GOA
part of eukaryotic translation initiation factor 2 complex IPI
IPI: Inferred from physical interaction
31836389 GOA
is active in mitochondrion IDA
IDA: Inferred from direct assay
38340717 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF2S1 Protein Structure

S1

S1: S1 RNA binding domain (14 - 88)

EIF_2_alpha

EIF_2_alpha: Eukaryotic translation initiation factor 2 alpha subunit (130 - 243)

  • 0
  • 100
  • 200
  • 300
  • 315 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 2 subunit 1

  • eIF-2-alpha

EIF2S1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
EIF2S1 P05198 EIF2S3 Homo sapiens P41091 33961781
Intra
EIF2S1 P05198 EIF2S3 Homo sapiens P41091 16288713
Intra
EIF2S1 P05198 EIF2S3 Homo sapiens P41091
Y3H
37507029
Cross
EIF2S1 P05198 Eif2ak3 Mus musculus Q9Z2B5 16288713
Cross
EIF2S1 P05198 Eif2ak3 Mus musculus Q9Z2B5 16288713
Intra
EIF2S1 P05198 VAC14 Homo sapiens Q08AM6 32296183
Intra
EIF2S1 P05198 VAC14 Homo sapiens Q08AM6 32296183
Intra
EIF2S1 P05198 VAC14 Homo sapiens Q08AM6 32296183
Intra
EIF2S1 P05198 PRMT7 Homo sapiens Q9NVM4 32296183
Intra
EIF2S1 P05198 PRMT7 Homo sapiens Q9NVM4 33961781
Intra
EIF2S1 P05198 ACTN1 Homo sapiens P12814 32296183
Intra
EIF2S1 P05198 EIF2AK2 Homo sapiens P19525 16288713
Intra
EIF2S1 P05198 EIF2S2 Homo sapiens P20042 16932749
Intra
EIF2S1 P05198 EIF2S2 Homo sapiens P20042 16288713
Cross: Cross-species interaction Intra: Intraspecies interaction

EIF2S1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P80811 Phospho-EIF2S1 (Ser51) Antibody (YA203) WB Human, Mouse, Rat
HY-P80811A Phospho-EIF2S1 (Ser51) Antibody (YA203)(PBS only) WB Human, Mouse, Rat
HY-P83763 EIF2S1 Antibody(YA3562) WB, ICC/IF, IHC-P, FC, IP Human, Mouse, Rat, Monkey
HY-P85616 EIF2S1 Antibody (YA5308) WB, ICC/IF, IP Human, Mouse, Rat
HY-P86063 Phospho-EIF2S1(Ser51) Antibody (YA5755) WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P86419 EIF2S1 Antibody (YA6111) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Vaccinia
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus
  • Wolcott-Rallison Syndrome

  • Med-Iddm Syndrome

  • Iddm-Med Syndrome

  • Wolcott Rallison Syndrome

  • WRS

  • Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

  • Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

  • Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

Fatty Liver Disease
  • Alcoholic Fatty Liver

  • Fatty Liver

  • Fatty Liver, Alcoholic

  • Fatty Change Of Liver

  • Hepatic Lipidosis

  • Steatosis Of Liver

  • Fatty Liver Alcoholic

  • Steatohepatitis

  • Etoh Fatty Liver

  • Etoh Fatty Liver Metamorphosis

  • Fatty Etoh Liver Necrosis

Cowpox
  • Yaba

Rift Valley Fever
  • Rfv - [Rift Valley Fever]

Newcastle Disease
  • Newcastle'S Disease

  • Pseudo-Fowlpest

Liver Disease
  • Liver Failure

  • Liver Diseases

  • Abnormality Of The Liver

  • Liver Dysfunction

  • Disorder Of Liver

  • Hepatic Disorder

  • Hepatic Disease

  • Disease Of Bilirubin Metabolism

  • Disorder Of Bilirubin Metabolism

  • Liver Decompensation

  • Liver Function Failure

  • Hepatic Failure Nos

  • Liver Failure Nos

  • End Stage Liver Disease

  • Decompensated Liver Failure

  • Decompensation Of Liver Function

  • Hepatic Decompensation

  • Hepatic Insufficiency

  • Liver Cell Necrosis With Hepatic Failure

  • Liver Insufficiency

  • Decompensated Liver Disease

  • End Stage Liver Failure

  • Liver Necrosis With Hepatic Failure

Influenza
  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified

Yellow Fever
  • Urban Yellow Fever

  • Jungle Yellow Fever

  • Sylvatic Yellow Fever

  • Yf

  • Yellow Fever, Sylvan

  • Bronze John

  • Yellow Jack

  • Yf- [Yellow Fever]

  • Febris Flava

Leukoencephalopathy With Vanishing White Matter
  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter

Mehmo Syndrome
  • Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

  • MEHMO

  • Mrxs20

  • Mrxs25

  • X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome

  • Mrxsbrk

  • Mental Retardation, X-Linked, Syndromic 20

  • Mental Retardation, X-Linked, Syndromic 25

  • Mental Retardation, X-Linked, Syndromic, Borck Type

  • Syndromic X-Linked Mental Retardation 20

  • Syndromic X-Linked Mental Retardation 25

  • Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

  • X-Linked Mehmo Syndrome

Viral Infectious Disease
  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections

Dystonia 16
  • DYT16

  • Dyt-Prkra

  • Dystonia-16

  • Young-Onset Dystonia-

  • Early-Onset Dystonia Parkinsonism

  • Dystonia, Type 16

Beta-Thalassemia
  • Beta Thalassemia

  • Cooley'S Anemia

  • Mediterranean Anemia

  • Beta Thalassemia Intermedia

  • Erythroblastic Anemia

  • Thalassemia, Hispanic Gamma-Delta-Beta

  • Thalassemia Major

  • Thalassemia Minor

  • Beta-Plus-Thalassemia

  • Thalassemia, Beta

  • Beta Thalassemia Major

  • Beta Thalassemia Minor

  • Thalassemias, Beta-

  • Microcytemia, Beta Type

  • Thalassemia, Beta Type

  • B-THAL

  • Mediterranean Anaemia

  • Beta Thalassaemia Syndrome

  • Mediterranean Disease

  • Beta Thalassaemia Disease

Melanoma In Congenital Melanocytic Nevus
  • Malignant Melanoma In Congenital Melanocytic Nevus

  • Melanocytic Nevi

  • Nevi Melanocytic

Retinal Degeneration
  • Degeneration Of Retina

Dystonia
  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Amyotrophic Lateral Sclerosis 1
  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus EIF2S1 VGNC VGNC:28390
Canis familiaris EIF2S1 VGNC VGNC:40266
Mus musculus EIF2S1 MGD MGI:95299
Macaca mulatta EIF2S1 VGNC VGNC:72187
Felis catus EIF2S1 VGNC VGNC:61778
Rattus norvegicus EIF2S1 RGD RGD:620963
Others EIF2S1 NCBI