Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

Mus musculus

Also known as Pek; Perk

Gene ID: 13666 | Gene type: protein coding

About Eif2ak3

Chromosome 6: 70,821,499-70,882,229 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 197 orthologues, 8 paralogues and is associated with 41 phenotypes. Ubiquitous expression in placenta adult (RPKM 1.8), colon adult (RPKM 7.9) and 28 other tissues.

Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

Eif2ak3 Products(2)

mRNA	Protein	Name
NM_001313918.1	NP_001300847.1	eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor
NM_010121.3	NP_034251.2	eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor

Eif2ak3 Protein Structure

Luminal_EIF2AK3

PKc_like

STKc_EIF2AK3_PERK

0
200
400
600
800
1000
1114 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 2-alpha kinase 3

PRKR-like endoplasmic reticulum kinase

pancreatic eIF2-alpha kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119240	CCT020312	Activator	99.28%	Unkown
HY-RS04244	EIF2AK3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04245	Eif2ak3 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04246	Eif2ak3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak3	NCBI	NCBI:9451

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