Mfn2 - mitofusin 2 Gene

Also Known as Fzo; D630023P19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170731

Summary

Predicted to enable several functions, including GTP binding activity; GTPase activity; and enzyme binding activity. Involved in mitochondrial fusion; parkin-mediated stimulation of Mitophagy in response to mitochondrial depolarization; and positive regulation of cold-induced thermogenesis. Acts upstream of or within blastocyst formation and camera-type eye morphogenesis. Located in microtubule Cytoskeleton and mitochondrion. Is expressed in several structures, including brain; early conceptus; eye; heart; and oocyte. Used to study Charcot-Marie-Tooth disease type 2A2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Apr 2022]

Mfn2 Products (7)

mRNA Protein Name
NM_001285920.1 NP_001272849.1 mitofusin-2
NM_001285921.1 NP_001272850.1 mitofusin-2
NM_001285922.1 NP_001272851.1 mitofusin-2
NM_001285923.1 NP_001272852.1 mitofusin-2
NM_001355590.1 NP_001342519.1 mitofusin-2
NM_001355591.1 NP_001342520.1 mitofusin-2
NM_133201.3 NP_573464.2 mitofusin-2
Protein Preferred Names Protein Names

mitofusin-2

  • HSG protein

  • hypertension related protein 1

  • mitochondrial assembly regulatory factor

  • transmembrane GTPase MFN2

Mfn2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mfn2 Q80U63 Eif2ak3 Mus musculus Q9Z2B5
Anti Tag CoIP
23921556
Cross
Mfn2 Q80U63 BAK1 Homo sapiens Q16611
Anti Tag CoIP
17606912
Intra
Mfn2 Q80U63 Bak1 Mus musculus O08734
Anti Bait CoIP
19168699
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150031 MFI8 Inhibitor 99.67% Unkown
HY-W187305 MASM7 99.85% Unkown
HY-126124 AP39 96.35% Unkown
HY-123985 MFN2 agonist-1 Activator 98.84% Unkown
HY-W018587 TBPH 95.0% Unkown
HY-13338 Mabuterol Agonist 99.96% Unkown
HY-P4890A Relaxin H3 (human) TFA / Unkown
HY-P4890 Relaxin H3 (human) / Unkown
HY-RS08384 MFN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-152051S Mabuterol-d9 hydrochloride Agonist / Unkown
HY-RS17108 Mfn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23553 Mfn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W755295 Mabuterol hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mfn2 NCBI NCBI:9927