F7 - coagulation factor VII Gene
Also Known as SPCA
Species: Homo sapiens
About F7
This gene has 6 transcripts (splice variants), 335 orthologues, 16 paralogues and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 23.8).
Summary
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, Factor Xa, factor XIIa, or Thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to Factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
F7 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_000131.4 | NP_000122.1 | coagulation factor VII isoform a preproprotein |
| NM_001267554.2 | NP_001254483.1 | coagulation factor VII isoform c precursor |
| NM_019616.4 | NP_062562.1 | coagulation factor VII isoform b precursor |
F7 Protein Structure
Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (65 - 106)
EGF: EGF-like domain (110 - 140)
Trypsin: Trypsin (213 - 447)
- 0
- 100
- 200
- 300
- 400
- 466 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
coagulation factor VII |
|
F7 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
F7 | P08709 | F3 | Homo sapiens | P13726 | 15522303 | |
|
Intra
|
F7 | P08709 | F3 | Homo sapiens | P13726 | 9414278 | |
|
Intra
|
F7 | P08709 | F3 | Homo sapiens | P13726 | 15664864 | |
|
Intra
|
F7 | P08709 | F3 | Homo sapiens | P13726 | 8598903 | |
|
Intra
|
F7 | P08709 | F3 | Homo sapiens | P13726 | 8940045 |
Recombinant F7 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P74239 | Coagulation Factor VII/F7 Protein, Human (HEK293, His, solution) | P08709-1 (A61-P466) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78763 | Coagulation factor VII/F7 Protein, Human (HEK293, His) | P08709-1 (A61-P466) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700565 | Coagulation factor VII/F7 Protein, Human (His-SUMO) | P08709-1 (A61-R212) | ≥ 90%, as determined by reducing SDS-PAGE. |
F7 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P810283 | Factor VII Antibody (YA9627) | WB, ICC/IF, IF-Tissue, IHC-P, ELISA | human |
| HY-P811174 | Factor VII Antibody | WB, ICC/IF | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Factor Vii Deficiency |
|
|
| Myocardial Infarction |
|
|
| Hemophilia A |
|
|
| Factor V Deficiency |
|
|
| Hemophilia B |
|
|
| Dubin-Johnson Syndrome |
|
|
| Factor Xii Deficiency |
|
|
| Thrombophilia |
|
|
| Budd-Chiari Syndrome |
|
|
| Thrombosis |
|
|
| Hemorrhagic Disease |
|
|
| Von Willebrand'S Disease |
|
|
| Disseminated Intravascular Coagulation |
|
|
| Prothrombin Deficiency |
|
|
| Synovial Angioma |
|
|
| Factor Viii Deficiency |
|
|
| Qualitative Platelet Defect |
|
|
| Carotid Stenosis |
|
|
| Factor X Deficiency |
|
|
| Hemarthrosis |
|
|
| Vitamin K Deficiency Bleeding |
|
|
| Acute Myocardial Infarction |
|
|
| Dic In Newborn |
|
|
| Factor Xi Deficiency |
|
|
| Blood Coagulation Disease |
|
|
| Coumarin Resistance |
|
|
| Compartment Syndrome |
|
|
| Acquired Von Willebrand Syndrome |
|
|
| Cardiovascular System Disease |
|
|
| Factor Xiii Deficiency |
|
|
| Benign Chronic Pemphigus |
|
|
| Nonbacterial Thrombotic Endocarditis |
|
|
| Pulmonary Artery Disease |
|
|
| Glanzmann Thrombasthenia 1 |
|
|
| Coronary Heart Disease 1 |
|
|
| Cerebral Palsy |
|
|
| Afibrinogenemia, Congenital |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Vein Disease |
|
|
| Active Peptic Ulcer Disease |
|
|
| Thrombophlebitis |
|
|
| Portal Vein Thrombosis |
|
|
| Placental Abruption |
|
|
| Bernard-Soulier Syndrome |
|
|
| Sodoku Disease |
|
|
| Blood Platelet Disease |
|
|
| Spondylocostal Dysostosis 3, Autosomal Recessive |
|
|
| Stroke, Ischemic |
|
|
| Scoliosis |
|
|
| Deficiency Anemia |
|
|
| Patent Foramen Ovale |
|
|
| Alpha-2-Plasmin Inhibitor Deficiency |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Malignant Secondary Hypertension |
|
|
| Diabetes Mellitus |
|
|
| Hypertension, Essential |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | F7 | VGNC | VGNC:72466 |
| Canis familiaris | F7 | VGNC | VGNC:40552 |
| Felis catus | F7 | VGNC | VGNC:62028 |
| Mus musculus | F7 | MGD | MGI:109325 |
| Rattus norvegicus | F7 | RGD | RGD:628678 |
| Bos taurus | F7 | VGNC | VGNC:28689 |
| Others | F7 | NCBI |