Benzyl 2-cyclopropyl-2-hydroxyacetate
Based on 1 Customer Validation
Benzyl 2-cyclopropyl-2-hydroxyacetate is a glycolate ester and a Camptothecin (HY-16560) derivative payload component used for the preparation of antibody-drug conjugates. Benzyl 2-cyclopropyl-2-hydroxyacetate functions as the cytotoxic payload moiety of the conjugate linker. Benzyl 2-cyclopropyl-2-hydroxyacetate can be used in cancer research.
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- 純度 : 98.43%
- CAS 番号: 182747-31-5
- 分子式: C12H14O3
- 分子量:206.24
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Benzyl 2-cyclopropyl-2-hydroxyacetate (compound 40c) is prepared by dissolving compound 40b (11.5 g, 0.099 mol) in acetonitrile (50 mL), sequentially adding potassium carbonate (54.65 g, 0.396 mol), benzyl bromide (17.03 g, 0.099 mol), and tetrabutylammonium iodide (3.66 g, 0.0099 mol), and stirring at room temperature for 48 h; the reaction mixture is filtered through celite, the filter cake is rinsed with ethyl acetate, and the filtrate is concentrated and purified by silica gel column chromatography.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 182747-31-5
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性状 Liquid (Density: 1.234±0.06 g/cm3)
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分子量 206.24
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分子式 C12H14O3
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Color Colorless to light yellow
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SMILES
O=C(C(C1CC1)O)OCC2=CC=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
プロトコル
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
純度とドキュメンテーション
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データシート (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Benzyl 2-cyclopropyl-2-hydroxyacetate 関連分類
HY-46572 関連分類
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