HPV18-IN-1
HPV18-IN-1 (Compound H1) is a potent inhibitor of HPV18. HPV18-IN-1 prevents cervical cancer cells from premature cell procession and abnormal proliferation. HPV18-IN-1 supresses E7-Rb-E2F cellular pathway and DNA methylation. HPV18-IN-1 has the potential for the research of cancer diseases.
For research use only. We do not sell to patients.
- CAS No.: 331851-78-6
- Formula: C14H10N4OS
- Molecular Weight:282.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| C-33-A | IC50 |
11.93 μM
Compound: 1; H1
|
Antiproliferative activity against human C-33-A cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human C-33-A cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 32739649] |
| HEK293 | IC50 |
>20 μM
Compound: 1; H1
|
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 32739649] |
| HeLa | IC50 |
0.38 μM
Compound: 1; H1
|
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 32739649] |
| SiHa | IC50 |
11.51 μM
Compound: 1; H1
|
Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 32739649] |
Chemical Information
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CAS No. 331851-78-6
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Molecular Weight 282.32
-
Formula C14H10N4OS
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SMILES
NC1=CC=C(OC(C2=CC=C3N=C(N)SC3=C2)=N4)C4=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)