GPI - glucose-6-phosphate isomerase Gene

Also Known as AMF; NLK; PGI; PHI; GNPI; SA36; SA-36

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2821

About GPI

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:34,359,718-34,402,413 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 278 orthologues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 54.9), fat (RPKM 52.6) and 25 other tissues.

Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GPI Products (7)

mRNA	Protein	Name
NM_000175.5	NP_000166.2	glucose-6-phosphate isomerase isoform 2
NM_001184722.1	NP_001171651.1	glucose-6-phosphate isomerase isoform 1
NM_001289789.1	NP_001276718.1	glucose-6-phosphate isomerase isoform 3
NM_001289790.3	NP_001276719.1	glucose-6-phosphate isomerase isoform 4
NM_001329909.1	NP_001316838.1	glucose-6-phosphate isomerase isoform 2
NM_001329910.1	NP_001316839.1	glucose-6-phosphate isomerase isoform 2
NM_001329911.2	NP_001316840.1	glucose-6-phosphate isomerase isoform 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables glucose-6-phosphate isomerase activity	IDA IDA: Inferred from direct assay	28803808	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27499296	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24810856	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	28803808	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	1649192	GOA
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	3020690	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPI Protein Structure

PGI

0
100
200
300
400
500
558 a.a.

Protein Preferred Names	Protein Names
glucose-6-phosphate isomerase	autocrine motility factor

Recombinant GPI Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71680	Glucose-6-phosphate isomerase Protein, Human (His)	P06744-1 (A2-E554)	≥ 95%, as determined by reducing SDS-PAGE.

GPI Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P810641	Glucose 6 phosphate isomerase Antibody (YA9903)	WB, IHC-P, FC, ICC/IF, IF-Tissue	Human
HY-P82032	AMF Antibody (YA1777)	WB, IHC-P, ICC/IF, FC	Human
HY-P83978	Glucose-6-phosphate isomerase Antibody (YA3675)	IHC-P, ICC/IF, ELISA	Human
HY-P83978A	Glucose-6-phosphate isomerase Antibody (YA3675)(PBS only)	IHC-P, ICC/IF, ELISA	Human
HY-P85191	AMF Antibody (YA4883)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency	Hemolytic Anemia Due To Glucophosphate Isomerase Deficiency Hemolytic Anemia, Non-Spherocytic, Due To Glucose Phosphate Isomerase Deficiency HA-GPID Anemia, Hemolytic, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Congenital Nonspherocytic Hemolytic Anemia	Hereditary Non-Spherocytic Hemolytic Anemia Hereditary Nonspherocytic Hemolytic Anemia Anemia, Hemolytic, Congenital Nonspherocytic Congenital Nonspherocytic Hemolytic Anaemia Hereditary Nonspherocytic Hemolytic Anaemia Hnsha
Cutaneous Leishmaniasis	Diffuse Cutaneous Leishmaniasis Asian Desert Cutaneous Leishmaniasis Leishmaniasis, Cutaneous Leproid Leishmaniasis Leishmaniasis Diffuse Cutaneous Leishmaniasis Cutaneous Ethiopian Cutaneous Leishmaniasis Old World Cutaneous Leishmaniasis
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Transient Arthritis
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Hyperoxaluria, Primary, Type Iii	Primary Hyperoxaluria Type 3 HP3 Ph Iii Primary Hyperoxaluria Type Iii Hyperoxaluria Primary 3 Hyperoxaluria Non-Hp1/Non-Hp2 Hyperoxaluria Non-Ph I/Ph Ii Form Hyperoxaluria Primary Type Iii
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Alveolar Echinococcosis	Echinococcus Multilocularis Infection Echinococcosis Alveolococcosis Multilocular Hydatid Small Fox Tapeworm
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia
Triosephosphate Isomerase Deficiency	TPID Triose Phosphate-Isomerase Deficiency Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency Tpi Deficiency Triose Phosphate Isomerase Deficiency Deficiency Of Phosphotriose Isomerase Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema	Dehydrated Hereditary Stomatocytosis Hereditary Xerocytosis Xerocytosis, Hereditary Pshk1 Pseudohyperkalemia Edinburgh Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema DHS1 Dhs Hereditary Desiccytosis Dehydrated Hereditary Stomatocytosis 1 Desiccytosis, Hereditary Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak Pseudohyperkalemia Familial 1, Due To Red Cell Leak Desiccytosis Hereditary Xerocytosis Hereditary Familial Pseudohyperkalemia 1 Due To Red Cell Leak Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema Xerocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P2918	Phosphoglucose Isomerase, Rabbit muscle		/	Phase 4
HY-136424	GPI-1485		99.56%	Phase 2
HY-18233	Manogepix	Inhibitor	99.57%	Phase 1

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99006	Amatuximab	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-108615	CP-316819	Inhibitor	99.0%	Unkown
HY-19396	Ingliforib	Inhibitor	99.07%	Unkown
HY-129035	PFI-653	Inhibitor	99.92%	Unkown
HY-103345	2-MPPA	Inhibitor	98.0%	Unkown
HY-124619	GPI-1046		99.79%	Unkown
HY-N6841	Rhodiolin		98%	Unkown
HY-13540	E7016	Inhibitor	98.11%	Unkown
HY-P1596	Gluten Exorphin C	Inhibitor	99.86%	Unkown
HY-131455A	Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA		98.0%	Unkown
HY-18233S	Manogepix-d4		/	Unkown
HY-105450	GPI-3000	Antagonist	/	Unkown
HY-108614	GPi688	Inhibitor	/	Unkown
HY-118945	FR191413		/	Unkown
HY-145316	Vanin-1-IN-2	Inhibitor	/	Unkown
HY-15048	GPI 15427	Inhibitor	/	Unkown
HY-164813	oxLig-1	Activator	/	Unkown
HY-175250	TNF-α-IN-25	Inhibitor	/	Unkown
HY-177636	GPI2A	Inhibitor	/	Unkown
HY-177636A	GPI2A sodium	Inhibitor	/	Unkown
HY-177636B	GPI2A sodium scrambled negative control	Inhibitor	/	Unkown
HY-177636C	FAM labled GPI2A sodium		/	Unkown
HY-177636D	Cy3 labled GPI2A sodium		/	Unkown
HY-P3632	[DAla2, DArg6] Dynorphin A, (1-13) (porcine)		/	Unkown
HY-P3809	[D-Pro2,D-Phe7,D-Trp9] Substance P		/	Unkown
HY-RS05571	GNPDA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05639	GPI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-108615R	CP-316819 (Standard)	Inhibitor	/	Unkown
HY-182471	Aminopyrifen	Inhibitor	98.85%	Unkown
HY-RS23184	Gpi Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPI	VGNC	VGNC:41381
Felis catus	GPI	VGNC	VGNC:67409
Bos taurus	GPI	VGNC	VGNC:29534
Rattus norvegicus	GPI	RGD	RGD:2727
Mus musculus	GPI	MGD	MGI:95797
Macaca fascicularis	GPI	NCBI	NCBI:101865104
Macaca mulatta	GPI	NCBI	NCBI:717980
Others	GPI	NCBI