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GPI-1485 (Synonyms: GM1485)

Cat. No.: HY-136424
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GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke.

For research use only. We do not sell to patients.

GPI-1485 Chemical Structure

GPI-1485 Chemical Structure

CAS No. : 186268-78-0

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Description

GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1].

In Vitro

GPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF)[1].

Cell Viability Assay[1]

Cell Line: Normal human dermal fibroblasts (NHDF)[1]
Concentration: 100 μM
Incubation Time:
Result: Induced cellular reprogramming and neural cell induction.
In Vivo

GPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats[1].

Animal Model: Adult male Wistar rats, weighing 250-300 g[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily; for a total of 42 days
Result: Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats.
Molecular Weight

241.28

Formula

C₁₂H₁₉NO₄

CAS No.

186268-78-0

SMILES

O=C(O)[[email protected]]1N(C(C(C(C)(C)CC)=O)=O)CCC1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GPI-1485GM1485GPI1485GPI 1485GM 1485GM-1485OthersimmunophilinligandneurofunctionalneuralregenerationstrokeInhibitorinhibitorinhibit

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