Ikzf1 - IKAROS family zinc finger 1 Gene

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in erythrocyte differentiation; lymphocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; neural retina development; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and pericentric heterochromatin. Predicted to be part of protein-DNA complex. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Orthologous to human IKZF1 (IKAROS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]