MAP3K11 - mitogen-activated protein kinase kinase kinase 11 Gene

Also Known as MLK3; PTK1; SPRK; MLK-3; MEKK11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4296

About MAP3K11

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,597,757-65,614,221 (from NCBI)

This gene has 13 transcripts (splice variants), 184 orthologues and 23 paralogues. Ubiquitous expression in spleen (RPKM 25.3), fat (RPKM 22.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

MAP3K11 Products (1)

mRNA Protein Name
NM_002419.4 NP_002410.1 mitogen-activated protein kinase kinase kinase 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables JUN kinase kinase kinase activity IMP
IMP: Inferred from mutant phenotype
15258589 GOA
enables MAP kinase kinase kinase activity IMP
IMP: Inferred from mutant phenotype
15258589 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
9829970 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
17584736 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9003777 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
9829970 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8195146 GOA
Biological Process GO Annotation Evidence Références Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15258589 GOA
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
15258589 GOA
involved in cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
15258589 GOA
involved in microtubule-based process IMP
IMP: Inferred from mutant phenotype
12529434 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
17584736 GOA
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
17584736 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
8195146 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11053428 GOA
Cellular Component GO Annotation Evidence Références Source
located in centrosome IDA
IDA: Inferred from direct assay
12529434 GOA
located in microtubule IDA
IDA: Inferred from direct assay
12529434 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K11 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (48 - 100)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (117 - 376)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 11

  • SH3 domain-containing proline-rich kinase

MAP3K11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MAP3K11 Q16584 NF2 Homo sapiens P35240
Pull Down
20890305
Intra
MAP3K11 Q16584 NF2 Homo sapiens P35240
Anti Bait CoIP
20890305
Intra
MAP3K11 Q16584 NF2 Homo sapiens P35240
Protein Kinase Assay
20890305
Cross
MAP3K11 Q16584 Map4k1 Mus musculus P70218
Anti Tag CoIP
9003777
Intra
MAP3K11 Q16584 CDC42 Homo sapiens P60953
Anti Tag CoIP
20890305
Intra
MAP3K11 Q16584 CDC42 Homo sapiens P60953
PLA
25241761
Cross
MAP3K11 Q16584 Q99IB8-PRO_0000045602 Hepatitis C virus Q99IB8-PRO_0000045602
Anti Bait CoIP
23857585
Cross
MAP3K11 Q16584 Q99IB8-PRO_0000045602 Hepatitis C virus Q99IB8-PRO_0000045602
Anti Tag CoIP
23857585
Cross
MAP3K11 Q16584 Q99IB8-PRO_0000045602 Hepatitis C virus Q99IB8-PRO_0000045602
Confocal
23857585
Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K11 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83492 MLK3 Antibody (YA3237) WB, ICC/IF Human
HY-P83492A MLK3 Antibody (YA3237)(PBS only) WB, ICC/IF Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08048 MAP3K11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20638 Map3k11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27147 Map3k11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP3K11 RGD RGD:1359261
Bos taurus MAP3K11 VGNC VGNC:31189
Felis catus MAP3K11 VGNC VGNC:68156
Mus musculus MAP3K11 MGD MGI:1346880
Canis familiaris MAP3K11 VGNC VGNC:42967
Others MAP3K11 NCBI