SSTR3 - somatostatin receptor 3 Gene

Also Known as SS3R; SST3; SS3-R; SS-3-R; SSR-28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6753

About SSTR3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,204,237-37,220,548 (from NCBI)

This gene has 2 transcripts (splice variants), 251 orthologues and 17 paralogues. Biased expression in testis (RPKM 3.5), brain (RPKM 1.1) and 8 other tissues.

Summary

This gene encodes a member of the Somatostatin Receptor protein family. Somatostatins are peptide Hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many Hormones and Other secretory proteins. Somatostatin has two active forms of 14 and 28 Amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with Other members of the superfamily as well as with Other G-protein coupled receptors and Receptor Tyrosine Kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SSTR3 Products (6)

mRNA	Protein	Name
XM_006724311.4	XP_006724374.1	somatostatin receptor type 3 isoform X1
XM_047441473.1	XP_047297429.1	somatostatin receptor type 3 isoform X1
XM_005261721.5	XP_005261778.1	somatostatin receptor type 3 isoform X1
NM_001051.5	NP_001042.1	somatostatin receptor type 3
XM_017028924.2	XP_016884413.1	somatostatin receptor type 3 isoform X1
NM_001278687.2	NP_001265616.1	somatostatin receptor type 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19071123	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSTR3 Protein Structure

7tm_1

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
somatostatin receptor type 3

SSTR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SSTR3	P32745	SSTR2	Homo sapiens	P30874	IF	22651821
Intra	SSTR3	P32745	MPDZ	Homo sapiens	O75970	Anti Bait CoIP	19071123
Intra	SSTR3	P32745	MPDZ	Homo sapiens	O75970	IF	19071123
Cross	SSTR3	P32745	Mpdz	Rattus norvegicus	O55164	Pull Down	19071123

Cross: Cross-species interaction Intra: Intraspecies interaction

SSTR3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82287	Somatostatin Receptor 3 Antibody (YA2032)	WB	Human
HY-P82287A	Somatostatin Receptor 3 Antibody (YA2032)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Meckel Syndrome, Type 1	Meckel Syndrome Meckel-Gruber Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Gastrointestinal Neuroendocrine Tumor	Gastrointestinal Neuroendocrine Tumour Malignant Gastrointestinal Neuroendocrine Tumor Malignant Gastrointestinal Neuroendocrine Tumour Digestive System Neuroendocrine Neoplasm Digestive System Neuroendocrine Tumor
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Vipoma	Wdha Syndrome Pancreatic Cholera Pancreatic Vipoma Verner-Morrison Syndrome Diarrheogenic Islet Cell Tumor Vip-Secreting Tumor Malignant Vasoactive Intestinal Peptide-Secreting Tumor Vasoactive Intestinal Peptide-Secreting Tumor Vip- Secreting Tumor Vipoma, Malignant Vipoma Syndrome Watery Diarrhea Syndrome Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome Vasoactive Intestinal Peptide Tumor Vasoactive Intestinal Peptide-Producing Tumor Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome Malignant Vipoma
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Microcystic Meningioma
Pituitary Adenoma	Pituitary Neoplasms Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Hormone Producing Pituitary Cancer	Growth Hormone Producing Pituitary Tumor Pituitary Tumors, Hormone Producing Somatotropinoma Growth Hormone-Producing Pituitary Gland Neoplasm
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Hydrolethalus Syndrome 1	Hydrolethalus Syndrome HLS1 Salonen-Herva-Norio Syndrome Hls Hydrolethalus Hydrolethalus Syndrome, Type 1
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Hyperpituitarism
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Growth Hormone Secreting Pituitary Adenoma	Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma Growth Hormone Producing Adenoma Of The Pituitary Growth Hormone Secreting Adenoma Of Pituitary
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P0036	Octreotide	Agonist	99.96%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P0024	Veldoreotide	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P1932	Cortistatin-14		99.98%	Unkown
HY-P1203	BIM-23056	Antagonist	99.98%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.97%	Unkown
HY-P4452	PRL 2915	Antagonist	99.92%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-123335	L-796778	Agonist	98.00%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-177493	SSTR3 Agonist-1	Agonist	/	Unkown
HY-123460	BN-81674	Antagonist	/	Unkown
HY-P2150	Cortistatin-29 (rat)		/	Unkown
HY-P1203A	BIM-23056 TFA	Antagonist	/	Unkown
HY-177493A	SSTR3 agonist-1 TFA	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SSTR3	MGD	MGI:98329
Canis familiaris	SSTR3	VGNC	VGNC:46845
Rattus norvegicus	SSTR3	RGD	RGD:620308
Macaca mulatta	SSTR3	VGNC	VGNC:77894
Bos taurus	SSTR3	VGNC	VGNC:35327
Felis catus	SSTR3	VGNC	VGNC:65712
Others	SSTR3	NCBI