Cyp8b1 - cytochrome P450 family 8 subfamily B member 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81924

Summary

Enables sterol 12-alpha-hydroxylase activity. Involved in bile acid signaling pathway; response to cholesterol; and response to nutrient levels. Predicted to be located in endoplasmic reticulum membrane. Biomarker of extrahepatic cholestasis; non-alcoholic fatty liver disease; and premature menopause. Orthologous to human CYP8B1 (Cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp8b1 Products (1)

mRNA Protein Name
NM_031241.2 NP_112520.2 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables sterol 12-alpha-hydroxylase activity IDA
IDA: Inferred from direct assay
10393316 RGD
Biological Process GO Annotation Evidence Références Source
involved in response to cholesterol IEP
IEP: Inferred from expression pattern
25263431 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25263431 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

  • cytochrome P450, 8b1, sterol 12 alpha-hydrolase

  • cytochrome P450, family 8, subfamily b, polypeptide 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-113259 7α-Hydroxy-4-cholesten-3-one 99.60% Unkown
HY-113259S 7α-Hydroxy-4-cholesten-3-one-d7 ≥98.0% Unkown
HY-113259R 7α-Hydroxy-4-cholesten-3-one (Standard) / Unkown
HY-183692 FXR agonist 18 / Unkown
HY-RS03489 CYP8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17779 Cyp8b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24246 Cyp8b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp8b1 NCBI NCBI:1582