7α-Hydroxy-4-cholesten-3-one-d7
Based on 1 Customer Validation
7α-Hydroxy-4-cholesten-3-one-d7 is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.
For research use only. We do not sell to patients.
- Purity: 97.60%
- CAS No.: 2260669-17-6
- Formula: C27H37D7O2
- Molecular Weight:407.68
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2260669-17-6
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Unlabeled Cas 3862-25-7
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Appearance Solid
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Molecular Weight 407.68
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Formula C27H37D7O2
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Color White to off-white
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SMILES
C[C@H](CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)CC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (245.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Offei SD, et al. Chemical synthesis of 7α-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption. Steroids. 2019 Nov;151:108449. [Content Brief]
[3]. Gälman C, et al. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology. 2005 Nov;129(5):1445-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4529 mL | 12.2645 mL | 24.5290 mL | 61.3226 mL |
| 5 mM | 0.4906 mL | 2.4529 mL | 4.9058 mL | 12.2645 mL | |
| 10 mM | 0.2453 mL | 1.2265 mL | 2.4529 mL | 6.1323 mL | |
| 15 mM | 0.1635 mL | 0.8176 mL | 1.6353 mL | 4.0882 mL | |
| 20 mM | 0.1226 mL | 0.6132 mL | 1.2265 mL | 3.0661 mL | |
| 25 mM | 0.0981 mL | 0.4906 mL | 0.9812 mL | 2.4529 mL | |
| 30 mM | 0.0818 mL | 0.4088 mL | 0.8176 mL | 2.0441 mL | |
| 40 mM | 0.0613 mL | 0.3066 mL | 0.6132 mL | 1.5331 mL | |
| 50 mM | 0.0491 mL | 0.2453 mL | 0.4906 mL | 1.2265 mL | |
| 60 mM | 0.0409 mL | 0.2044 mL | 0.4088 mL | 1.0220 mL | |
| 80 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7665 mL | |
| 100 mM | 0.0245 mL | 0.1226 mL | 0.2453 mL | 0.6132 mL |
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