CYP8B1 - cytochrome P450 family 8 subfamily B member 1 Gene

Also Known as CP8B; CYP12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1582

About CYP8B1

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,872,192-42,875,879 (from NCBI)

This gene has 2 transcripts (splice variants), 254 orthologues and 1 paralogue.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two Steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of Cholesterol. This gene is unique among the Cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]

CYP8B1 Products (1)

mRNA Protein Name
NM_004391.3 NP_004382.2 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

CYP8B1 Protein Structure

p450

p450: Cytochrome P450 (34 - 491)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

  • 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase

CYP8B1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810864 Cytochrome P450 8B1 Antibody WB, IHC-P Human, Mouse, Rat
HY-P811006 Cytochrome P450 8B1/ CYP8B1 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Intrahepatic Cholestasis Of Pregnancy

  • Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Gravidic Intrahepatic Cholestasis

  • Pregnancy-Related Cholestasis

  • Icp

  • Pregnancy Related Cholestasis

  • Cholestasis, Intrahepatic Of Pregnancy

  • Familial Intrahepatic Cholestasis Of Pregnancy

  • Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Ricp

  • Obstetric Cholestasis
Extrahepatic Cholestasis

  • Cholestasis, Extrahepatic

  • Extrahepatic Biliary Stasis

  • Extrahepatic Obstructive Biliary Disease

  • Cholestasis Extrahepatic
Cholestasis, Progressive Familial Intrahepatic, 2

  • PFIC2

  • Cholestasis, Progressive Familial Intrahepatic 2

  • Progressive Familial Intrahepatic Cholestasis Type 2

  • Progressive Familial Intrahepatic Cholestasis 2

  • Bsep Deficiency

  • Recurrent Familial Intrahepatic Cholestasis 2

  • Benign Recurrent Intrahepatic Cholestasis 2

  • Severe Abcb11 Deficiency

  • Bric2

  • Cholestasis, Benign Recurrent Intrahepatic 2

  • Mild Abcb11 Deficiency

  • Cholestasis, Intrahepatic, Familial, Progressive, Type 2
Cholestasis, Benign Recurrent Intrahepatic, 1

  • Benign Recurrent Intrahepatic Cholestasis

  • BRIC1

  • Summerskill Syndrome

  • Bric

  • Summerskill-Walshe-Tygstrup Syndrome

  • Cholestasis, Benign Recurrent Intrahepatic

  • Benign Recurrent Intrahepatic Cholestasis 1

  • Benign Recurrent Intrahepatic Cholestasis Type 1

  • Bric Type 1

  • Low Gamma-Gt Familial Intrahepatic Cholestasis

  • Recurrent Familial Intrahepatic Cholestasis

  • Cholestasis, Benign Recurrent Intrahepatic 1

  • Mild Atp8b1 Deficiency

  • Recurrent Familial Intrahepatic Cholestasis 1

  • Abcb11-Related Intrahepatic Cholestasis

  • Atp8b1-Related Intrahepatic Cholestasis

  • Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

  • Progressive Intrahepatic Cholestasis

  • Cholestasis, Progressive Familial Intrahepatic 3

  • Bric - [Benign Recurrent Intrahepatic Cholestasis]
Cerebrotendinous Xanthomatosis

  • CTX

  • Cerebral Cholesterinosis

  • Cholestanol Storage Disease

  • Xanthomatosis, Cerebrotendinous

  • Sterol 27-Hydroxylase Deficiency

  • Xanthomatosis Cerebrotendinous

  • Cerebrotendinous Cholesterinosis

  • Cholestanolosis

  • Van Bogaert-Scherer-Epstein Disease
Progressive Familial Intrahepatic Cholestasis

  • Abcb4-Related Intrahepatic Cholestasis

  • Cholestasis, Progressive Familial Intrahepatic

  • Pfic

  • Byler Disease

  • Abcb11-Related Intrahepatic Cholestasis

  • Atp8b1-Related Intrahepatic Cholestasis

  • Bsep Deficiency

  • Byler Disease

  • Byler Syndrome

  • Fic1 Deficiency

  • Low Γ-Gt Familial Intrahepatic Cholestasis

  • Mdr3 Deficiency

  • Pfic

  • Cholestasis, Intrahepatic, Familial, Progressive

  • Pfic - [Progressive Familial Intrahepatic Cholestasis]
Bile Duct Disease

  • Bile Duct Diseases

  • Bile Duct Disorder

  • Disorder Of Bile Duct
Biliary Tract Disease

  • Biliary Tract Diseases

  • Biliary Tract Abnormality
Cholangitis, Primary Sclerosing

  • Primary Sclerosing Cholangitis

  • PSC

  • Sclerosing Cholangitis

  • Cholangitis, Sclerosing

  • Cholangitis Primary Sclerosing

  • Psc - [Primary Sclerosing Cholangitis]
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113259 7α-Hydroxy-4-cholesten-3-one 99.60% Unkown
HY-113259S 7α-Hydroxy-4-cholesten-3-one-d7 ≥98.0% Unkown
HY-113259R 7α-Hydroxy-4-cholesten-3-one (Standard) / Unkown
HY-183692 FXR agonist 18 / Unkown
HY-RS03489 CYP8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17779 Cyp8b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24246 Cyp8b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CYP8B1 VGNC VGNC:110278
Canis familiaris CYP8B1 VGNC VGNC:50380
Macaca mulatta CYP8B1 VGNC VGNC:103617
Rattus norvegicus CYP8B1 RGD RGD:71016
Felis catus CYP8B1 VGNC VGNC:103331
Mus musculus CYP8B1 MGD MGI:1338044
Others CYP8B1 NCBI