Lithium orotate
Based on 1 Customer Validation
Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease.
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- CAS No.: 5266-20-6
- Formule: C5H3LiN2O4
- Masse moléculaire:162.03
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Lithium orotate (0-500 μM; 16 h) has low binding ability to synthetic human Aβ1-42 fibrils and oligomers[2].
Lithium orotate (20-500 μM; 6 h pre-treatment) promotes microglial uptake and degradation of Aβ42 in BV2 microglial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3xTg mice carried APPSwe and tauP301L
mutant transgenes and ageing wild-type mice[2] -
Dosage:4.3 and 130 µM
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Administration:p.o.; in drinking water
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Result:Almost completely prevented Aβ plaque deposition and phospho-tau accumulation in 3xTg mice.
Reversed memory loss in 3xTg mice and improved.
Prevented age-related microgliosis, astrogliosis, synapse loss, and cognitive decline in wild-type mice.
Chemical Information
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CAS No. 5266-20-6
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Appearance Solid
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Masse moléculaire 162.03
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Formule C5H3LiN2O4
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SMILES
O=C1C=C(C(O[Li])=O)NC(N1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lithium orotate Related Classifications
HY-W841438 Related Classifications
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