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Cat. No.: HY-163892

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POLRMT-IN-1

POLRMT-IN-1 (compound S7) is a POLRMT inhibitor. POLRMT-IN-1 can be used in cancer-related research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₃H₂₄FNO₄
Masse moléculaire:397.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

POLRMT-IN-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

POLRMT-IN-1 (compound S7) is a POLRMT inhibitor. POLRMT-IN-1 can be used in cancer-related research^[1].

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
CAPAN-1	IC₅₀	0.404 μM Compound: S7	Antiproliferative activity against human CAPAN-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against human CAPAN-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]
HUVEC	IC₅₀	>50 μM Compound: S7	Antiproliferative activity against HUVEC cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against HUVEC cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]
MIA PaCa-2	IC₅₀	0.005 μM Compound: S7	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]
PANC-1	IC₅₀	0.198 μM Compound: S7	Antiproliferative activity against human PANC-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay Antiproliferative activity against human PANC-1 cells assessed as cell viability measured after 168 hrs incubation by SRB assay	[PMID: 39049433]

Chemical Information

Masse moléculaire 397.44
Formule C₂₃H₂₄FNO₄
SMILES

CC1=CC=CC=C1C(C2=C(C=C(C(F)=C2)O[C@@H](C(N(CC)CC)=O)C)O3)=CC3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhou S,et al. Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer. J Med Chem. 2024 Jul 24. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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POLRMT-IN-1

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

POLRMT-IN-1 Related Classifications

HY-163892 Related Classifications