PSMA-trillium
PSMA-trillium (Felivotide mopaxetan) is a PSMA-targeted molecule that contains a highly specific PSMA-binding motif, an albumin-binding domain optimized for tumor uptake and retention, and a Macropa chelator conjugated to the α-emitter 225Ac. PSMA-trillium binds to albumin to prolong plasma retention time and binds to PSMA via its specific motif. 225Ac-PSMA-Trillium exhibits dose-dependent inhibition of LNCaP tumor growth in mice. PSMA-trillium can be used in research related to prostate cancer and metastatic castration-resistant prostate cancer.
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- CAS No.: 3036415-37-6
- Formule: C106H156IN17O34S
- Masse moléculaire:2371.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
225Ac-PSMA-trillium maintains favorable stability for up to 48 h[1].
225Ac-PSMA-trillium (0.114 kBq/mL) potently induces cytotoxicity in C4-2, a subclone of the prostate cancer cell line LNCaP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID (male)[2]
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Dosage:100 kBq/kg; 400 kBq/kg
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Administration:i.v.; single injection
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Result:Showed higher tumor uptake compared to other 225Ac-PSMA-SMOLs, with homogeneous tumor accumulation 60 hours after injection and fast clearance from the kidneys.
Inhibited LNCaP tumor growth and decreased tumor weights in a dose-dependent manner.
Chemical Information
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CAS No. 3036415-37-6
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Masse moléculaire 2371.44
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Formule C106H156IN17O34S
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SMILES
O=C([C@@H](NC(N[C@H](C(O)=O)CCCCNC(NC1=CC(C2=CN(N=N2)CCOCCOCCOCCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(O)=O)CCCCNC(CCCC3=CC=C(I)C=C3)=O)=O)=O)CCCCNC(NC4=CC=C(C=C4)CCOC5=CC(C(O)=O)=NC(CN6CCOCCOCCN(CC7=CC=CC(C(O)=O)=N7)CCOCCOCC6)=C5)=S)=O)=CC=C1)=O)=O)CCC(O)=O)O
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Synonyms
Felivotide mopaxetan
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSMA-trillium Related Classifications
HY-158119A Related Classifications
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