Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study

  • Toxicology. 1975 Nov;5(2):237-41. doi: 10.1016/0300-483x(75)90120-1.
S K Tandon ,  J Singh
PMID: 1209652 DOI: 10.1016/0300-483x(75)90120-1
Abstract

Some Chelating Agents were examined for their ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate. Nitrilotriacetic acid (NTA), 1,2-cyclohexylenedinitrilotetraacetic acid (CDTA) and diethylenetriaminepentaacetic acid (DTPA) were extremely effective in vivo while CDTA and p-aminosalicylic acid (PAS) were efficient in vitro.

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