1,2-Cyclohexylenedinitrilotetraacetic acid
Based on 1 Customer Validation
1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 482-54-2
- Formula: C14H22N2O8
- Molecular Weight:346.33
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1,2-Cyclohexylenedinitrilotetraacetic acid is an analogue of EDTA, with the vinyl group replaced by a cyclohexenyl group and the two aminoacetic acid groups in a trans configuration. 1,2-Cyclohexylenedinitrilotetraacetic acid exhibits stronger lipophilicity and pre-organization ability, and forms more stable complex with metal ions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Manganese-induced acute neurotoxicity in Sprague-Dawley rats models[3]
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Dosage:36 mg/kg
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Administration:ip, once a day for two days
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Result:Reduced the manganese ion concentration in the brain tissue, prevented the occurance of pathological changes such as Alzheimer's type II astrocyte proliferation.
Chemical Information
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CAS No. 482-54-2
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Appearance Solid
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Molecular Weight 346.33
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Formula C14H22N2O8
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Color White to off-white
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SMILES
C1CCC(C(C1)N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
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Synonyms
CDTA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 5.71 mg/mL (16.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Tandon SK, et al. Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study. Toxicology. 1975 Nov;5(2):237-41. [Content Brief]
[2]. Sun Y, et al., Synthesis and characterization of racemic mixture and meso isomers of bis(trans-2-aminocyclohexyl)aminepentaacetic acid and the stabilities of their Gd(III) complexes. Inorg Chem. 2000 Apr 3;39(7):1480-6. [Content Brief]
[3]. Hazell AS, et al., Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett. 2006 Apr 3;396(3):167-71. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8874 mL | 14.4371 mL | 28.8742 mL | 72.1855 mL |
| 5 mM | 0.5775 mL | 2.8874 mL | 5.7748 mL | 14.4371 mL | |
| 10 mM | 0.2887 mL | 1.4437 mL | 2.8874 mL | 7.2185 mL | |
| 15 mM | 0.1925 mL | 0.9625 mL | 1.9249 mL | 4.8124 mL |
1,2-Cyclohexylenedinitrilotetraacetic acid Related Classifications
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