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  3. Drug Derivative
  4. Chondroitin sulfate-cholesterol

Chondroitin sulfate-cholesterol is a cholesterol derivative. Chondroitin sulfate-cholesterol can form reduction-responsive shell-sheddable micelles via disulfide bond linkage and be used to efficiently encapsulate hydrophobic drugs and achieve intracellular triggered release. Chondroitin sulfate-cholesterol can be used for cancer research.

For research use only. We do not sell to patients.

Chondroitin sulfate-cholesterol

Chondroitin sulfate-cholesterol Chemical Structure

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Chondroitin sulfate-cholesterol Related Antibodies

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Description

Chondroitin sulfate-cholesterol is a cholesterol derivative. Chondroitin sulfate-cholesterol can form reduction-responsive shell-sheddable micelles via disulfide bond linkage and be used to efficiently encapsulate hydrophobic drugs and achieve intracellular triggered release. Chondroitin sulfate-cholesterol can be used for cancer research[1].

In Vitro

Chondroitin sulfate-cholesterol can form micelles (S-ss-Chol), S-ss-Chol (0.02-200 μg/mL; 48 h) exhibit negligible cytotoxicity to HeLa cells at concentrations ≤20 μg/mL, slight cytotoxicity at 200 μg/mL, and no significant cytotoxicity to HSF cells at concentrations up to 200 μg/mL after 48 h incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chondroitin sulfate-cholesterol Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa (cancer), HSF (normal)
Concentration: 0.02, 0.2, 2, 20, 200 μg/mL (S-ss-Chol micelles)
Incubation Time: 48 h
Result: Maintained cell viability >80% for HeLa cells at concentrations ≤20 μg/mL, and near 80% at 200 μg/mL.
Maintained cell viability >90% for HSF cells at all concentrations up to 200 μg/mL.
Showed no significant morphological difference between HeLa cells treated with 200 μg/mL micelles and untreated controls, with only a slight decrease in cell number.
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[Chondroitin sulfate-cholesterol]
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Chondroitin sulfate-cholesterol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chondroitin sulfate-cholesterolDrug DerivativeDrug derivativecancer cellsdisulfide bondsintracellular reductive environmentsfibroblast cellsredox-responsiveHSF cellssugar receptorsquercetinmicellesHeLa cellsInhibitorinhibitorinhibit

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