country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-185474

Copy Link Print Information

Chondroitin sulfate-cholesterol

Chondroitin sulfate-cholesterol is a cholesterol derivative. Chondroitin sulfate-cholesterol can form reduction-responsive shell-sheddable micelles via disulfide bond linkage and be used to efficiently encapsulate hydrophobic drugs and achieve intracellular triggered release. Chondroitin sulfate-cholesterol can be used for cancer research.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Chondroitin sulfate-cholesterol Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Chondroitin sulfate-cholesterol can form micelles (S-ss-Chol), S-ss-Chol (0.02-200 μg/mL; 48 h) exhibit negligible cytotoxicity to HeLa cells at concentrations ≤20 μg/mL, slight cytotoxicity at 200 μg/mL, and no significant cytotoxicity to HSF cells at concentrations up to 200 μg/mL after 48 h incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa (cancer), HSF (normal)
Concentration:

0.02, 0.2, 2, 20, 200 μg/mL (S-ss-Chol micelles)
Incubation Time:

48 h
Result:

Maintained cell viability >80% for HeLa cells at concentrations ≤20 μg/mL, and near 80% at 200 μg/mL.
Maintained cell viability >90% for HSF cells at all concentrations up to 200 μg/mL.
Showed no significant morphological difference between HeLa cells treated with 200 μg/mL micelles and untreated controls, with only a slight decrease in cell number.

Chemical Information

SMILES

[Chondroitin sulfate-cholesterol]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu C, et al. Redox-responsive shell-sheddable micelles self-assembled from amphiphilic chondroitin sulfate-cholesterol conjugates for triggered intracellular drug release[J]. Chemical engineering journal, 2013, 228: 290-299.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote