2. Neuronal Signaling
  3. Serotonin Transporter
  4. CM 57373

CM 57373 is an orally active anorectic agent. CM 57373 releases serotonin and inhibits serotonin reuptake in rat brain synaptosomes. CM 57373 reduces food intake, decreases body weight and alleviates experimentally induced hyperphagia. CM 57373 can be used in obesity research.

For research use only. We do not sell to patients.

CM 57373

CM 57373 Chemical Structure

CAS No. : 98644-22-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CM 57373 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CM 57373 is an orally active anorectic agent. CM 57373 releases serotonin and inhibits serotonin reuptake in rat brain synaptosomes. CM 57373 reduces food intake, decreases body weight and alleviates experimentally induced hyperphagia. CM 57373 can be used in obesity research[1][2].

In Vitro

CM 57373 inhibits serotonin reuptake and releases serotonin in rat brain synaptosomes in vitro[1].
CM 57373 exhibits very low affinity for serotonin receptors in rat brain membranes in vitro, with potency less than one-hundredth that of m-chlorophenylpiperazine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CM 57373 Related Antibodies
In Vivo

CM 57373 (0.1-20 mg/kg; i.p.) dose-dependently decreases brain 5-HIAA concentrations in healthy male Sprague-Dawley rats, with significant reductions observed at doses ≥5 mg/kg i.p., and produces no consistent significant changes in brain serotonin concentrations[1].
CM 57373 (2.5-20 mg/kg; i.p.) antagonizes p-chloroamphetamine-induced brain serotonin depletion in healthy male Sprague-Dawley rats with an ED50 of 7 mg/kg, achieving complete restoration at a 20 mg/kg i.p. dose[1].
CM 57373 hydrochloride (3.75-15 mg/kg; p.o.; single dose) produces a dose-dependent anorectic effect in food-deprived female Sprague-Dawley rats with an oral ID50 of 7.4 mg/kg[2].
CM 57373 (1.25-10 mg/kg; p.o.; single dose) produces a dose-dependent anorectic effect in male and female Beagle dogs with an oral ID50 of 2.4 mg/kg and good tolerability[2].
CM 57373 (3-7.5 mg/kg; p.o.; single dose, daily via drinking water; 16 days) reduces cafeteria-diet hyperphagia in female Sprague-Dawley rats, with tolerance developing over 16 days; it lowers telencephalic 5-HIAA levels without altering 5-HT levels and sustains reduced body weights despite tolerance[2].
CM 57373 (7.5 mg/kg; p.o.; single dose) prevents insulin-induced hyperphagia in female Sprague-Dawley rats without altering insulin-induced hypoglycemia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 180-220 g)[1]
Dosage: 0.1 mg/kg; 1 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: i.p.
Result: Decreased brain 5-HIAA concentrations to 1.13 nmol/g, 1.10 nmol/g, and 0.98 nmol/g at 4 hours after 5 mg/kg, 10 mg/kg, and 20 mg/kg doses respectively (control = 1.65 nmol/g).
Produced no significant changes in brain serotonin concentrations at 4 hours after 5 mg/kg, 10 mg/kg, or 20 mg/kg doses.
Caused a small decrease in brain serotonin concentrations at 4 and 8 hours after 10 mg/kg dose, which was not consistent across studies.
Failed to produce significant effects on brain serotonin or 5-HIAA concentrations at 4 hours after 0.1 mg/kg or 1 mg/kg doses.
Reduced brain 5-HIAA concentrations within 1 hour after 10 mg/kg dose, with continued decrease up to 8 hours and recovery to control levels by 24 hours.
Animal Model: Sprague-Dawley (male, 180-220 g)[1]
Dosage: 2.5 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: i.p.
Result: Antagonized p-chloroamphetamine-induced brain serotonin depletion in a dose-dependent manner.
Restored brain serotonin concentrations to control levels (~3 nmol/g) after 20 mg/kg dose, achieving complete antagonism.
Had an estimated ED50 value of 7 mg/kg for antagonizing p-chloroamphetamine-induced brain serotonin depletion.
Animal Model: Sprague-Dawley (female, 175-200 g)[2]
Dosage: 3.75 mg/kg; 7.5 mg/kg; 15 mg/kg
Administration: p.o.; single dose
Result: Caused a dose-related reduction in food consumption.
Achieved an oral ID50 of 7.4 mg/kg.
Animal Model: Beagle (male and female, 11-14 kg, 5-10 per group)[2]
Dosage: 1.25 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration: p.o.; single dose
Result: Caused a dose-related reduction in food consumption.
Achieved an oral ID50 of 2.4 mg/kg.
Was well tolerated, with only moderate mydriasis observed at the 10 mg/kg dose.
Animal Model: Sprague-Dawley (female, initial weight 254 g)[2]
Dosage: 7.5 mg/kg (single dose on day 1, 8, and 16); 3 mg/kg (daily via drinking water for 16 days)
Administration: p.o.; single dose (day 1, 8, 16); daily via drinking water; 16 days
Result: Reduced 6-hour cafeteria food consumption to 5.03 g (52% of vehicle control levels, P < 0.01) on day 1.
Reduced 6-hour cafeteria food consumption to 8.00 g (56% of vehicle control levels, P < 0.01) on day 8.
Reduced 6-hour cafeteria food consumption to 9.70 g (76% of vehicle control levels, no significant difference from vehicle) on day 16.
Developed tolerance to the anorectic effect over 16 days, which was less pronounced on day 8 compared to dl-fenfluramine.
Lowered body weights early and maintained them below vehicle controls throughout the treatment period.
Did not modify telencephalic 5-HT levels on any day.
Reduced telencephalic 5-HIAA levels to 328 ng/g (day 1, P < 0.01), 236 ng/g (day 8, P < 0.01), and 305 ng/g (day 16, P < 0.01) relative to vehicle controls.
Animal Model: Sprague-Dawley (female, 175-200 g)[2]
Dosage: 7.5 mg/kg
Administration: p.o.; single dose
Result: Reduced 1-hour food intake to 0.73 g in saline-treated rats (P < 0.05 vs. vehicle).
Reduced 1-hour food intake to 0.47 g in insulin-treated rats (P < 0.01 vs. vehicle), preventing the insulin-induced increase in food intake.
Did not modify insulin-induced hypoglycemia, with plasma glucose levels of 51 mg% (vs. 45 mg% in insulin-only controls).
Molecular Weight

256.15

Formula

C10H14BrN3
CAS No.
SMILES

BrC=1N=C(C=CC1)N2CCC(N)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CM 57373 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM 5737398644-22-5CM57373CM-57373Serotonin Transporter5-HTTSERTSLC6A4serotonin uptake carrierrat brain membranescentral serotonergic receptorblood-brain barrierobesity5-hydroxyindoleacetic acidserotoninrat brain synaptosomesBeagle dogsSprague-Dawley ratsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CM 57373
Cat. No.:
HY-184316
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.