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  4. Peptidomimetics
  5. CPO_Aβ17-21P

CPO_Aβ17-21P is a apoE/Aβ interaction inhibitor with an IC50 of 1.02 nM. CPO_Aβ17-21P significantly inhibits ApoE4-mediated aggregation of Aβ40 and Aβ42. CPO_Aβ17-21P significantly improves cognitive function and comprehensively alleviates Alzheimer's disease (AD)-related pathologies in mouse models. CPO_Aβ17-21P is applicable to the research of AD.

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CPO_Aβ17-21P

CPO_Aβ17-21P Chemical Structure

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CPO_Aβ17-21P Related Antibodies

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Description

CPO_Aβ17-21P is a apoE/Aβ interaction inhibitor with an IC50 of 1.02 nM. CPO_Aβ17-21P significantly inhibits ApoE4-mediated aggregation of Aβ40 and Aβ42. CPO_Aβ17-21P significantly improves cognitive function and comprehensively alleviates Alzheimer's disease (AD)-related pathologies in mouse models. CPO_Aβ17-21P is applicable to the research of AD[1].

In Vitro

CPO_Aβ17-21P (2 μM; 7-10 d) potently inhibits apoE4-mediated fibrillization of Aβ40 and Aβ42[1].
CPO_Aβ17-21P (1-4 μM; 3 d) dose-dependently inhibits apoE4-enhanced Aβ42 cytotoxicity in human SK-N-SH neuroblastoma cells, and exerts significant rescue effects at concentrations of 1 μM and 4 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPO_Aβ17-21P Related Antibodies

Cell Viability Assay[1]

Cell Line: Human SK-N-SH neuroblastoma cells
Concentration: 1 μM, 4 μM
Incubation Time: 6 hrs (pre-incubation with apoE4 at 37 °C); 3 days (incubation with cells)
Result: Significantly neutralized apoE4-potentiated Aβ42 cytotoxicity at 1 μM.
Significantly neutralized apoE4-potentiated Aβ42 cytotoxicity at 4 μM.
Showed a greater rescue effect at the higher 4 μM concentration.
In Vivo

CPO_Aβ17-21P (0.2 mg per mouse; i.p.; twice weekly for 4 months) significantly alleviates Aβ pathology, neuroinflammation and cognitive impairment in the mouse brain, with no observed effects on motor function or plasma cholesterol levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP/PS1 transgenic mice (5 male, 6 female per group; 3 months old; Alzheimer's disease model)[1]
Dosage: 0.2 mg per mouse
Administration: i.p.; twice weekly; 4 months
Result: Improved spatial working memory.
Reduced total amyloid burden in the cortex and hippocampus compared to vehicle controls.
Reduced soluble Aβ40, insoluble Aβ40, and Aβ42 levels in brain tissue.
Reduced brain oligomeric Aβ levels.
Reduced hippocampal astrogliosis and cortical microgliosis.
Showed no significant difference in plasma total cholesterol levels compared to vehicle controls.
Showed no significant differences in locomotor activity, rotarod performance, or traverse beam performance compared to vehicle controls.
Molecular Weight

703.83

Formula

C37H49N7O7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CPO_Aβ17-21P Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPO_Aβ17-21PAlzheimer’s diseaseapoE4Aβ40neuroblastoma cellsAPP/PS1 transgenic miceSK-N-SHamyloid-β peptideAβ42N2aneuroinflammationInhibitorinhibitorinhibit

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