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Art. -Nr.: HY-170998

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ATG16L1 stabilizer-1

ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent ATG16L1 stabilizer that promotes cellular Autophagy. ATG16L1 stabilizer-1 inhibits ATG16L1 with an EC₅₀ of 12.1 μM in the presence or absence of FKBP12. ATG16L1 stabilizer-1 alone induces GFP-LC3 puncta formation to a small extent with an EC₅₀ of 12.0 μM.

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Formel: C₄₅H₆₂N₁₄O₅S

Molecular Weight:911.13

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ATG16L1 stabilizer-1 Chemical Structure

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Data Sheet (268 KB)

Handling Instructions (2659 KB)

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Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biologische Aktivität

Beschreibung

ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent ATG16L1 stabilizer that promotes cellular Autophagy. ATG16L1 stabilizer-1 inhibits ATG16L1 with an EC₅₀ of 12.1 μM in the presence or absence of FKBP12. ATG16L1 stabilizer-1 alone induces GFP-LC3 puncta formation to a small extent with an EC₅₀ of 12.0 μM^[1].

Chemical Information

Molecular Weight 911.13

Formel C₄₅H₆₂N₁₄O₅S

SMILES

O=C(C(C(C)(C)CC)=O)N1CCCC[C@@]1([H])C(N[C@@](CCC2=CC=C(OC)C=C2)([H])C(N3[C@@H]4C[C@H](NC5=NC(N6CCN7C(C6)=NC=N7)=NC(NCCC8=C(C)N=C(N)S8)=N5)C[C@H]3CC4)=O)=O

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Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Tan ZY, et al. Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell Chem Biol. 2024 Dec 30:S2451-9456(24)00491-4. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

ATG16L1 stabilizer-1 Related Classifications

HY-170998 Related Classifications

Autophagy

Autophagy

Disease Areas

Inflammation or Immune System Disease

Inflammation/Immunology

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Keywords

ATG16L1 stabilizer-1
Autophagy
human genetics
FKBP12-recruiting
Crohn’s disease
Inhibitor
inhibitor
inhibit

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