COX-2-IN-61
COX-2-IN-61 is an orally active COX-2 inhibitor with an IC50 of 22 µM, also inhibits COX-1 with an IC50 of 43 µM. COX-2-IN-61 exhibits anti-inflammation effects in a Carrageenan (HY-125474) induced rat paw edema model, with promising safety profiles. COX-2-IN-61 can be used for the research of inflammation.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C15H13N3O3S2
- Molecular Weight:347.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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COX-1 43 μM (IC50) |
COX-2 22 μM (IC50) |
COX-2-IN-61 (compound 4) forms hydrogen bonds with Arg513 and Ala527, and hydrophobic interactions with Val523, Met522, and Val349, which contribute to its binding to COX-2 and anti-inflammatory effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
COX-2-IN-61 (50 mg/kg, p.o., daily for 14 days) shows lower ulcerogenicity, cardiotoxicity and nephrotoxicity in rats, compared to Celecoxib[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (180-225 g) induced by Carrageenan (1%, 1 mL) injection[1]
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Dosage:50 mg/kg
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Administration:p.o., single dose
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Result:Showed significant anti-inflammatory activity, with 47% edema inhibition at 6 hours.
Demonstrated equal anti-inflammatory activity to Celecoxib after 4h interval.
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Animal Model:Male Wistar rats (180-225 g)[1]
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Dosage:50 mg/kg
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Administration:p.o., daily for 14 days
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Result:Markedly reduced histopathological damage of the stomach, heart, and kidney, compared to Celecoxib.
Resulted in a significantly lower increase in cardiac biomarkers (CK-MB, troponin I, AST, LDH) and renal injury biomarkers (creatinine, urea), compared to Celecoxib.
Chemical Information
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Molecular Weight 347.41
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Formel C15H13N3O3S2
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SMILES
O=S(C1=CC=C(N2N=C(C3=CC=CS3)C(/C=N/O)=C2)C=C1)(C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
COX-2-IN-61 Related Classifications
HY-179700 Related Classifications
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