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Art. -Nr.: HY-163445

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NAMPT activator-6

NAMPT activator-6 is a nicotinamide phosphoribosyltransferase (NAMPT) activator. NAMPT activator-6 can be used for the synthesis of PROTACs, such as PROTAC NAMPT Degrader-1 (HY-163440). NAMPT activator-6 applies to the research of ovarian cancer.

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CAS. Nr.: 2237267-86-4
Formel: C₁₇H₂₁N₅O₃S
Molecular Weight:375.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NAMPT activator-6 Chemical Structure

CAS. Nr.: 2237267-86-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

NAMPT activator-6 serves as the target protein ligand for PROTAC NAMPT Degrader-1 (HY-163440), a potent PROTAC targeting NAMPT with a DC₅₀ value of 217 nM^[1].
NAMPT activator-6 (example 210) has NAMPT activator activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2237267-86-4
Molecular Weight 375.45
Formel C₁₇H₂₁N₅O₃S
SMILES

O=C(NCC1=CC=NC=C1)NC2=CC=C(S(=O)(N3CCNCC3)=O)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cheng J, et al.. Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD. Angewandte Chemie (International ed. in English). 2024 Mar 18;63(12):e202315997. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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