RANBP9 - RAN binding protein 9 Gene

Also Known as BPM-L; BPM90; RANBPM; RanBP7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10048

About RANBP9

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,621,498-13,711,835 (from NCBI)

This gene has 2 transcripts (splice variants), 233 orthologues and 3 paralogues. Broad expression in testis (RPKM 72.2), esophagus (RPKM 38.9) and 23 other tissues.

Summary

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the Ras superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several Other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, Androgen Receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]

RANBP9 Products (1)

mRNA Protein Name
NM_005493.3 NP_005484.2 ran-binding protein 9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
17087506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12220523 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23118896 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15381419 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12220523 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29911972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANBP9 Protein Structure

SPRY

SPRY: SPRY domain (213 - 332)

LisH

LisH: LisH (369 - 392)

CLTH

CLTH: CTLH/CRA C-terminal to LisH motif domain (403 - 708)

  • 0
  • 200
  • 400
  • 600
  • 729 a.a.
Protein Preferred Names Protein Names

ran-binding protein 9

  • Ran Binding Protein in the Microtubule organizing center

RANBP9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RANBP9 Q96S59 OPRM1 Homo sapiens P35372
Y2H
23840749
Intra
RANBP9 Q96S59 OPRM1 Homo sapiens P35372
Pull Down
23840749
Intra
RANBP9 Q96S59 S100A7 Homo sapiens P31151
Y2H
12421467
Intra
RANBP9 Q96S59 PPP1CC Homo sapiens P36873-2
Y2H
21382349
Intra
RANBP9 Q96S59 DISC1 Homo sapiens Q9NRI5
Y2H
12812986
Intra
RANBP9 Q96S59 DYRK1B Homo sapiens Q9Y463
Pull Down
14500717
Intra
RANBP9 Q96S59 ENTPD1 Homo sapiens P49961
Anti Bait CoIP
16478441
Intra
RANBP9 Q96S59 ENTPD1 Homo sapiens P49961
Anti Tag CoIP
16478441
Cross: Cross-species interaction Intra: Intraspecies interaction

RANBP9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85542 RanBP9 Antibody (YA5234) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Lissencephaly 1

  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11649 RANBP9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22209 Ipo9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RANBP9 VGNC VGNC:102500
Mus musculus RANBP9 MGD MGI:1928741
Canis familiaris RANBP9 VGNC VGNC:49679
Rattus norvegicus RANBP9 RGD RGD:1561940
Macaca mulatta RANBP9 VGNC VGNC:76475
Bos taurus RANBP9 VGNC VGNC:33712
Others RANBP9 NCBI