CHGA - chromogranin A Gene
Also Known as CGA; PHE5; PHES
Species: Homo sapiens
About CHGA
This gene has 6 transcripts (splice variants), 1 gene allele, 178 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 574.1), stomach (RPKM 148.9) and 5 other tissues.
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two Other peptides, catestatin and chromofungin, have antimicrobial activity and Antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
CHGA Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001275.4 | NP_001266.1 | chromogranin-A isoform 1 preproprotein |
| NM_001301690.2 | NP_001288619.1 | chromogranin-A isoform 2 preproprotein |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in defense response to Gram-negative bacterium |
IDA
IDA: Inferred from direct assay
|
15723172 | GOA |
| involved in defense response to Gram-positive bacterium |
IDA
IDA: Inferred from direct assay
|
15723172 | GOA |
| involved in mast cell activation |
IDA
IDA: Inferred from direct assay
|
21214543 | GOA |
| involved in mast cell chemotaxis |
IDA
IDA: Inferred from direct assay
|
21214543 | GOA |
| involved in mast cell degranulation |
IDA
IDA: Inferred from direct assay
|
21214543 | GOA |
| involved in negative regulation of catecholamine secretion |
IDA
IDA: Inferred from direct assay
|
15326220 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
20862257 | GOA |
CHGA Protein Structure
Granin: Granin (chromogranin or secretogranin) (25 - 89)
Granin: Granin (chromogranin or secretogranin) (90 - 457)
- 0
- 100
- 200
- 300
- 400
- 457 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
chromogranin-A |
|
Recombinant CHGA Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71727 | CHGA Protein, Human (P.pastoris, His) | P10645 (L19-G457) | ≥ 90%, as determined by reducing SDS-PAGE. |
CHGA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82751 | Chromogranin A Antibody (YA2496) | WB | Rat |
| HY-P84048 | Chromogranin A Antibody (YA3745) | WB, IHC-P, FC, ELISA | Human |
| HY-P84048A | Chromogranin A Antibody (YA3745)(PBS only) | WB, IHC-P, FC, ELISA | Human |
| HY-P85880 | Chromogranin A Antibody (YA5572) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P85986 | Chromogranin A Antibody (YA5678) | IHC-P, ELISA | Human, Mouse, |
| HY-P86527 | Chromogranin A Antibody (YA6219) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Acinar Cell Carcinoma |
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| Neuroendocrine Carcinoma |
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| Neuroendocrine Tumor |
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| Large Cell Carcinoma |
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| Somatostatinoma |
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| Glucagonoma |
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| Vipoma |
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| Gastrinoma |
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| Atrophic Gastritis |
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| Merkel Cell Carcinoma |
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| Islet Cell Tumor |
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| Zollinger-Ellison Syndrome |
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| Paraganglioma |
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| Endocrine Gland Cancer |
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| Multiple Endocrine Neoplasia, Type I |
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| Sclerosing Hemangioma |
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| Multiple Endocrine Neoplasia |
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| Ganglioglioma |
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| Parathyroid Adenoma |
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| Pulmonary Sclerosing Hemangioma |
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| Tubular Adenocarcinoma |
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| Pheochromocytoma |
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| Pulmonary Neuroendocrine Tumor |
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| Carcinoid Tumors, Intestinal |
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| Mixed Ductal-Endocrine Carcinoma |
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| Olfactory Neuroblastoma |
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| Colon Neuroendocrine Neoplasm |
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| Gastritis |
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| Goblet Cell Carcinoid |
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| Insulinoma |
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| Endodermal Sinus Tumor |
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| Vaginal Glandular Tumor |
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| Primary Hyperparathyroidism |
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| Gastrointestinal Neuroendocrine Tumor |
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| Cervical Large Cell Neuroendocrine Carcinoma |
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| Appendix Carcinoid Tumor |
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| Thymus Small Cell Carcinoma |
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| Large Cell Neuroendocrine Carcinoma |
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| Lung Large Cell Carcinoma |
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| Pulmonary Blastoma |
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| Carcinoid Syndrome |
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| Gastrointestinal Neuroendocrine Benign Tumor |
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| Gastric Small Cell Carcinoma |
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| Thyroid Carcinoma, Familial Medullary |
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| Nonsyndromic Paraganglioma |
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| Pulmonary Large Cell Neuroendocrine Carcinoma |
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| Binswanger'S Disease |
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| Ganglioneuroma |
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| Signet Ring Cell Adenocarcinoma |
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| Breast Neuroendocrine Neoplasm |
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| Esophageal Neuroendocrine Tumor |
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| Hyperparathyroidism |
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| Ureter Small Cell Carcinoma |
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| Small Cell Cancer Of The Lung |
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| Blastoma |
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| Papillary Carcinoma |
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| Serotonin Syndrome |
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| Benign Ileal Neoplasm |
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| Gastric Gastrinoma |
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| Lung Cancer |
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| Ovarian Large-Cell Neuroendocrine Carcinoma |
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| Central Neurocytoma |
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| Adenoma |
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| Pituitary Adenoma |
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| Cystadenoma |
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| Female Urethral Cancer |
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| Gastric Neuroendocrine Neoplasm |
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| Malignant Pheochromocytoma |
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| Adrenal Medulla Cancer |
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| Adult Teratoma |
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| Conn'S Syndrome |
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| Adrenal Cortical Adenoma |
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| Laryngeal Neuroendocrine Tumor |
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| Benign Teratoma |
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| Non-Functioning Pancreatic Endocrine Tumor |
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| Pancreatic Acinar Cell Adenocarcinoma |
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| Lung Benign Neoplasm |
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| Adenosquamous Carcinoma |
|
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| Prostate Cancer |
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| Acinar Cell Cystadenocarcinoma |
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| Malignant Olfactory Nerve Neoplasm |
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| Small Intestine Benign Neoplasm |
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| Middle Ear Adenoma |
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| Auditory System Benign Neoplasm |
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| Hemangioma |
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| Adrenal Carcinoma |
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| Gastric Adenocarcinoma |
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| Pancreas Lymphoma |
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| Pineocytoma |
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| Duodenal Gastrinoma |
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| Peripheral Nervous System Benign Neoplasm |
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| Autonomic Nervous System Benign Neoplasm |
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| Adenocarcinoma |
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| Pancreatic Gastrinoma |
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| Ampulla Of Vater Benign Neoplasm |
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| Pancreatic Cholera |
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| Duodenal Benign Neoplasm |
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| Auditory System Cancer |
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| Thyroid Gland Cancer |
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| Pancreatic Ductal Carcinoma |
|
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| Irritable Bowel Syndrome |
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| Small Cell Carcinoma |
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| Pancreatic Serous Cystic Neoplasm |
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| Prostate Neuroendocrine Neoplasm |
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| Basaloid Squamous Cell Carcinoma |
|
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| Hypoglycemia |
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| Cranial Nerve Malignant Neoplasm |
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| Cervix Small Cell Carcinoma |
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| Sensory Organ Benign Neoplasm |
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| Pancreatic Cystadenoma |
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| Ectopic Cushing Syndrome |
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| Microcystic Adenoma |
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| Pancreatic Endocrine Carcinoma |
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| Inflammatory Bowel Disease |
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| Pancreatoblastoma |
|
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| Vulvar Eccrine Porocarcinoma |
|
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| Urinary Bladder Small Cell Neuroendocrine Carcinoma |
|
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| Teratoma |
|
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| Constipation |
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| Vaginal Tubulovillous Adenoma |
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| Extra-Adrenal Pheochromocytoma |
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| Cauda Equina Neoplasm |
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| Thyroid Gland Medullary Carcinoma |
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| Hyperinsulinemic Hypoglycemia, Familial, 2 |
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| Eyelid Benign Neoplasm |
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| Endocrine Pancreas Disease |
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| Pick Disease Of Brain |
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| Cerebral Neuroblastoma |
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| Endocrine Organ Benign Neoplasm |
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| Tuberous Sclerosis |
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| Gallbladder Small Cell Carcinoma |
|
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| Adrenal Cortical Carcinoma |
|
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| Cecal Disease |
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| Gallbladder Adenocarcinoma |
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| Microscopic Colitis |
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| Lymphocytic Colitis |
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| Pancreatic Cancer |
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| Persistent Generalized Lymphadenopathy |
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| Lung Oat Cell Carcinoma |
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| Appendiceal Neoplasm |
|
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| Budd-Chiari Syndrome |
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| Glomangioma |
|
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| Breast Papillary Carcinoma |
|
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| Adrenal Neuroblastoma |
|
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| Pancreatic Serous Cystadenoma |
|
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| Mediastinal Cancer |
|
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| Prolactinoma |
|
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| Pineal Region Choriocarcinoma |
|
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| Autoimmune Gastritis |
|
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| Gangliocytoma |
|
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| Appendix Adenocarcinoma |
|
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| Benign Perivascular Tumor |
|
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| Duodenal Somatostatinoma |
|
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| Pulmonary Valve Insufficiency |
|
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| Endometrial Small Cell Carcinoma |
|
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| Nodular Ganglioneuroblastoma |
|
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| Pernicious Anemia |
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| Laryngeal Small Cell Carcinoma |
|
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| Tricuspid Valve Stenosis |
|
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| Papillary Thymic Adenocarcinoma |
|
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| Cystic Teratoma |
|
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| Jejunal Cancer |
|
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| Liver Leiomyosarcoma |
|
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| Basal Cell Carcinoma |
|
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| Diarrhea 4, Malabsorptive, Congenital |
|
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| Ovarian Small Cell Carcinoma |
|
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| Cutaneous Ganglioneuroma |
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| Meckel Diverticulum |
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| Oligodendroglioma |
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| Lung Disease |
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| Vaginal Adenoma |
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| Clear Cell Basal Cell Carcinoma |
|
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| Adrenal Gland Disease |
|
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| Gastrointestinal System Benign Neoplasm |
|
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| Sclerosing Hepatic Carcinoma |
|
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| Small Intestine Neuroendocrine Neoplasm |
|
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| Duodenum Cancer |
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| Ganglioneuroblastoma |
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| Gastric Cancer |
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| Duodenum Disease |
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| Carotid Body Cancer |
|
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| Ovary Leiomyosarcoma |
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| Suppression Of Tumorigenicity 12 |
|
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| Mixed Cell Type Cancer |
|
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| Von Hippel-Lindau Syndrome |
|
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| Lung Combined Large Cell Neuroendocrine Carcinoma |
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| Intrahepatic Bile Duct Adenoma |
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| Hyperinsulinemic Hypoglycemia |
|
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| Ewing Sarcoma |
|
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| Vaginal Benign Neoplasm |
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| Rhabdomyosarcoma |
|
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| Thymus Large Cell Carcinoma |
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| Cardiovascular Organ Benign Neoplasm |
|
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| Respiratory System Benign Neoplasm |
|
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| Neuroblastoma |
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| Heart Disease |
|
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| Thyroid Gland Hurthle Cell Carcinoma |
|
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| Lung Clear Cell Carcinoma |
|
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| Hypertension, Essential |
|
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| Gastric Hemangioma |
|
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| Solid Adenocarcinoma With Mucin Production |
|
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| Diabetes Mellitus |
|
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| Breast Cancer |
|
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| Gastrointestinal Stromal Tumor |
|
|
| Patent Foramen Ovale |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CHGA | VGNC | VGNC:27289 |
| Mus musculus | CHGA | MGD | MGI:88394 |
| Felis catus | CHGA | VGNC | VGNC:60854 |
| Macaca mulatta | CHGA | VGNC | VGNC:71032 |
| Rattus norvegicus | CHGA | RGD | RGD:2338 |
| Others | CHGA | NCBI |