Chromogranin A Antibody (YA2496)
(Synonyms: beta Granin; Chromogranin A; ChrA; SP-I; Vasostatin I; Vasostatin-2; Vasostatin II; Pancreastatin; CHGA)Chromogranin A Antibody (YA2496) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Chromogranin A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Chromogranin A Antibody (YA2496) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Chromogranin A.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityRat
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Observed Molecular WeightObserved band size: 92 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Entrez Gene: 24258 Rat
SwissProt: P10354 Rat
A synthetic peptide of human Chromogranin A
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Chromogranin A is a Strongly inhibits glucose induced insulin release from the pancreas; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Acts as a potent scavenger of free radicals in vitro. May play a role in the regulation of cardiac function and blood pressure; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation[1][2][3][4][5].
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Subcellular Localization
Secreted; Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle; Secreted
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Expression
Tissue_specificity:Protein levels were detected in cerebrospinal fluid (PubMed: 25326458) . Protein levels were detected in urine (PubMed: 37453717) ; it was also found in brain tissue. -
Subunit
Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (PubMed:25326458).
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SwissProt ID
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Synonyms
beta Granin; Chromogranin A; ChrA; SP-I; Vasostatin I; Vasostatin-2; Vasostatin II; Pancreastatin; CHGA
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Research Field
Neuroscience
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