Chromogranin A Antibody (YA3745)
(Synonyms: CGA)Chromogranin A Antibody (YA3745) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Chromogranin A.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
Chromogranin A Antibody (YA3745) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Chromogranin A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Purified recombinant fragment of human CHGA (AA: 278-457) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Chromogranin A is a Strongly inhibits glucose induced insulin release from the pancreas; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Acts as a potent scavenger of free radicals in vitro. May play a role in the regulation of cardiac function and blood pressure; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation[1][2][3][4][5].
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Subcellular Localization
Secreted; Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle; Secreted
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Expression
Tissue_specificity:Protein levels were detected in cerebrospinal fluid (PubMed: 25326458) . Protein levels were detected in urine (PubMed: 37453717) ; it was also found in brain tissue. -
Subunit
Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (PubMed:25326458).
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SwissProt ID
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Synonyms
CGA
Documentation
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