IL34 - interleukin 34 Gene

Also Known as IL-34; C16orf77

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146433

About IL34

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,579,899-70,660,682 (from NCBI)

This gene has 5 transcripts (splice variants) and 91 orthologues. Biased expression in spleen (RPKM 59.9), skin (RPKM 16.8) and 5 other tissues.

Summary

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

IL34 Products (9)

mRNA Protein Name
NM_001172771.2 NP_001166242.1 interleukin-34 isoform 2 precursor
NM_001172772.2 NP_001166243.1 interleukin-34 isoform 1 precursor
NM_001393493.1 NP_001380422.1 interleukin-34 isoform 1 precursor
NM_001393494.1 NP_001380423.1 interleukin-34 isoform 1 precursor
NM_001393495.1 NP_001380424.1 interleukin-34 isoform 2 precursor
NM_001393496.1 NP_001380425.1 interleukin-34 isoform 2 precursor
NM_001393497.1 NP_001380426.1 interleukin-34 isoform 3
NM_001393498.1 NP_001380427.1 interleukin-34 isoform 4
NM_152456.3 NP_689669.2 interleukin-34 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22483114 GOA
enables macrophage colony-stimulating factor receptor binding IDA
IDA: Inferred from direct assay
18467591 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22483114 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-34-mediated signaling pathway IDA
IDA: Inferred from direct assay
26754294 GOA
acts upstream of or within positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
26754294 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18467591 GOA
acts upstream of positive regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
26754294 GOA
involved in positive regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
23409120 GOA
acts upstream of positive regulation of macrophage proliferation IDA
IDA: Inferred from direct assay
26754294 GOA
involved in positive regulation of monocyte differentiation IDA
IDA: Inferred from direct assay
23409120 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18467591 GOA
acts upstream of or within positive regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
26754294 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18467591 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL34 Protein Structure

IL34

IL34: Interleukin 34 (24 - 185)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

interleukin-34

IL34 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL34 Q6ZMJ4 LCE1F Homo sapiens Q5T754
Y2H Array
32296183
Intra
IL34 Q6ZMJ4 LCE1F Homo sapiens Q5T754
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL34 Proteins

Cat. No. Product Name Accession Purity
HY-P73211 IL-34 Protein, Human (CHO, His) Q6ZMJ4-1/AAH29804.1 (N21-P242) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700125AF Animal-Free IL-34 Protein, Human (His) Q6ZMJ4-1 (N21-P242) ≥ 95%, as determined by reducing SDS-PAGE.

IL34 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84649 IL34 Antibody (YA4346) WB, ICC/IF, FC, ELISA Human
HY-P84649A IL34 Antibody (YA4346)(PBS only) WB, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

  • Hereditary Diffuse Leukoencephalopathy With Spheroids

  • Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

  • Alsp

  • Gpsc

  • Subcortical Gliosis Of Neumann

  • Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1

  • Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids

  • Hdls

  • HDLS1

  • Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia

  • Gliosis, Familial Progressive Subcortical

  • Leukoencephalopathy, Diffuse Hereditary, With Spheroids

  • Pold

  • Pigmentary Orthochromatic Leukodystrophy

  • Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

  • Familial Progressive Subcortical Gliosis

  • Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant

  • Dementia, Familial, Neumann Type

  • Adult-Onset Leukodystrophy With Neuroaxonal Spheroids

  • Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids

  • Neuroaxonal Leukodystrophy

  • Fpsg

  • Familial Dementia, Neumann Type

  • Familial Dementia Neumann Type

  • Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Tenosynovial Giant Cell Tumor

  • Fibrous Histiocytoma Of Tendon Sheath

  • Giant Cell Tumor Of Tendon Sheath

  • Giant Cell Tumor Of Tenosynovium

  • Giant Cell Tumour Of Tendon Sheath

  • Giant Cell Tumour Of Tenosynovium

  • Tenosynovial Giant Cell Tumour

  • Diffuse-Type Gct

  • Diffuse-Type Giant Cell Tumor

  • Pigmented Villonodular Synovitis

  • Tgct

  • Tsgct
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Pigmented Villonodular Synovitis

  • Diffuse Giant Cell Tumor Of Tenosynovium

  • Villous Tenosynovitis

  • Diffuse Pigmented Villonodular Synovitis

  • Diffuse-Type Gct

  • Diffuse-Type Giant Cell Tumor

  • Localized Pigmented Villonodular Synovitis

  • Tgct

  • Tsgct

  • Tenosynovial Giant Cell Tumor

  • Tenosynovial Giant Cell Tumors

  • Synovitis Pigmented Villonodular

  • Synovitis, Pigmented Villonodular

  • Fibrous Histiocytoma Of Tendon Sheath

  • Testicular Germ Cell Tumor

  • Chronic Haemorrhagic Villous Synovitis

  • Pvns - [Pigmented Villonodular Synovitis]

  • Villonodular Synovitis
Gallbladder Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Gallbladder

  • Epidermoid Gallbladder Carcinoma
Peripheral Nerve Schwannoma
Chronic Apical Periodontitis

  • Apical Periodontitis Nos

  • Apex Periodontitis

  • Periapical Infection Nos
Bone Benign Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991048 AMG-820 Inhibitor 98% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06758 IL34 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174606 Human IL34 mRNA / Unkown
HY-RS17538 Il34 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23995 Il34 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992249 Anti-IL-34 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL34 MGD MGI:1923777
Macaca mulatta IL34 VGNC VGNC:73669
Rattus norvegicus IL34 RGD RGD:1586038
Bos taurus IL34 VGNC VGNC:30156
Canis familiaris IL34 VGNC VGNC:41983
Felis catus IL34 VGNC VGNC:62913
Others IL34 NCBI