DKK1 - dickkopf WNT signaling pathway inhibitor 1 Gene

Also Known as SK; DKK-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22943

About DKK1

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:52,314,281-52,317,657 (from NCBI)

This gene has 4 transcripts (splice variants), 130 orthologues and is associated with 2 phenotypes. Biased expression in placenta (RPKM 39.1), urinary bladder (RPKM 8.2) and 3 other tissues.

Summary

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in Cancer cell lines. [provided by RefSeq, Sep 2017]

DKK1 Products (1)

mRNA	Protein	Name
NM_012242.4	NP_036374.1	dickkopf-related protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables co-receptor binding	IPI IPI: Inferred from physical interaction	11433302	GOA
enables low-density lipoprotein particle receptor binding	IDA IDA: Inferred from direct assay	16263759	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11448771	GOA
enables receptor antagonist activity	IDA IDA: Inferred from direct assay	20723538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	20559569	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	15020244	GOA
involved in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	IDA IDA: Inferred from direct assay	11448771	GOA
involved in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	IPI IPI: Inferred from physical interaction	11433302	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11433302	GOA
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18166153	GOA
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	27846906	GOA
involved in negative regulation of cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	20559569	GOA
involved in negative regulation of mesodermal cell fate specification	IDA IDA: Inferred from direct assay	20559569	GOA
involved in negative regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20723538	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	20093360	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20723538	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	23164821	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23164821	GOA
involved in regulation of endodermal cell fate specification	IDA IDA: Inferred from direct assay	20559569	GOA
involved in regulation of receptor internalization	IDA IDA: Inferred from direct assay	17804805	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11448771	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16263759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DKK1 Protein Structure

Dickkopf_N

0
100
200
266 a.a.

Protein Preferred Names	Protein Names
dickkopf-related protein 1	dickkopf 1 homolog

DKK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DKK1	O94907	KREMEN1	Homo sapiens	Q96MU8	X-Ray Diffraction	27524201
Intra	DKK1	O94907	MDFI	Homo sapiens	Q99750	Y2H Array	19060904
Intra	DKK1	O94907	MDFI	Homo sapiens	Q99750	Y2H Pooling	19060904
Intra	DKK1	O94907	LRP6	Homo sapiens	O75581	Pull Down	11448771
Intra	DKK1	O94907	LRP6	Homo sapiens	O75581	Anti Tag CoIP	33961781
Intra	DKK1	O94907	LRP6	Homo sapiens	O75581	Anti Tag CoIP	28514442
Intra	DKK1	O94907	LRP6	Homo sapiens	O75581	X-Ray Diffraction	27524201
Intra	DKK1	O94907	LRP6	Homo sapiens	O75581	ELISA	11448771

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DKK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7155A	DKK-1 Protein, Human (HEK293, His)	O94907 (T32-R265)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70513	DKK-1 Protein, Human (HEK293, N-His)	O94907 (T32-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72968	DKK-1 Protein, Human (HEK293, Fc)	O94907 (T32-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78887	DKK-1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	O94907 (T32-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7155B	DKK-1 Protein, Human (HEK293)	O94907 (T32-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700704	DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi)	O94907 (M178-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700705	DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi)	O94907 (T32-D142)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700863	DKK-1 Protein, Human (89a.a, HEK293, mFc)	O94907 (M178-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700884	DKK-1 C terminal Domain Protein, Human (Biotinylated, HEK293, Fc-Avi)	O94907 (M178-H266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700885	DKK-1 N terminal Domain Protein, Human (Biotinylated, HEK293, Fc-Avi)	O94907 (T32-D142)	≥ 95%, as determined by reducing SDS-PAGE.

DKK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82961	Dkk-1 Antibody (YA2706)	WB, IHC-P, ICC/IF, FC	Human, Rat
HY-P85122	Dkk-1 Antibody (YA4814)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Chiari Malformation Type I	Chiari Malformation Type 1 Arnold-Chiari Malformation Type I Cm1 Arnold-Chiari Malformation Type 1 Chiari Type 1 Malformation Malformation, Chiari, Type I Arnold-Chiari Malformation, Type I Arnold-Chiari Obstruction Type I
Osteoporosis, Juvenile	Idiopathic Juvenile Osteoporosis Idiopathic Osteoporosis Juvenile Osteoporosis Ijo
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Chiari Malformation
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Diffuse Idiopathic Skeletal Hyperostosis	Hyperostosis, Diffuse Idiopathic Skeletal Ankylosing Vertebral Hyperostosis Dish Disseminated Idiopathic Skeletal Hyperostosis Forestier Disease Forestier'S Disease Hyperostosis Diffuse Idiopathic Skeletal
Spondylitis
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Androgenic Alopecia	Androgenetic Alopecia Alopecia Androgenetica, Male Pattern Baldness
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Alopecia
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Osteopetrosis, Autosomal Dominant 1	OPTA1 Autosomal Dominant Osteopetrosis 1 Autosomal Dominant Osteopetrosis Type 1 Osteopetrosis Autosomal Dominant Type 1 Osteopetrosis, Autosomal Dominant, Type I Osteopetrosis, Autosomal Dominant, Type 1
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Bone Resorption Disease	Bone Resorption
Bone Remodeling Disease
Ankylosis
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Alzheimer Disease 9	AD9 Alzheimer'S Disease 9 Alzheimer Disease 9, Susceptibility To Alzheimer Disease 9, Late-Onset Alzheimer'S Disease 9, Late Onset {Alzheimer Disease 9, Susceptibility To}
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Ischemic Bone Disease
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14930A	Mirodenafil dihydrochloride		99.11%	Unkown
HY-14930	Mirodenafil		99.88%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99906	Sirexatamab		99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11035	WAY-262611		99.96%	Unkown
HY-D0961	Gallocyanine chloride	Activator	92.00%	Unkown
HY-N5124	Meloside A	Inhibitor	98.72%	Unkown
HY-N2276	Nodakenetin	Activator	99.66%	Unkown
HY-RS03787	DKK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-14930S	Mirodenafil-d7		/	Unkown
HY-162970	XD23	Activator	/	Unkown
HY-175219	CA-II/Dkk1-IN-1	Inhibitor	/	Unkown
HY-W185542	E09241		/	Unkown
HY-RS16543	Dkk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22975	Dkk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992113	Evabosmig	Inhibitor	/	Unkown
HY-P991569	PF-04840082	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DKK1	MGD	MGI:1329040
Canis familiaris	DKK1	VGNC	VGNC:52929
Macaca mulatta	DKK1	VGNC	VGNC:71801
Rattus norvegicus	DKK1	RGD	RGD:1307313
Bos taurus	DKK1	VGNC	VGNC:28079
Others	DKK1	NCBI