EXOSC2 - exosome component 2 Gene

Also Known as p7; RRP4; SHRF; Rrp4p; hRrp4p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23404

About EXOSC2

Cytogenetic location: 9q34.12 Genomic coordinates (GRCh38): 9:130,693,760-130,704,894 (from NCBI)

This gene has 34 transcripts (splice variants), 210 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 5.3), ovary (RPKM 5.1) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in positive regulation of cell growth. Located in cytoplasm; nucleolus; and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC2 Products (3)

mRNA	Protein	Name
NM_001282708.1	NP_001269637.1	exosome complex component RRP4 isoform 2
NM_001282709.1	NP_001269638.1	exosome complex component RRP4 isoform 3
NM_014285.7	NP_055100.2	exosome complex component RRP4 isoform 1

EXOSC2 Protein Structure

ECR1_N

0
100
200
293 a.a.

Protein Preferred Names	Protein Names
exosome complex component RRP4	exosome complex exonuclease RRP4

EXOSC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EXOSC2	Q13868	ZNF408	Homo sapiens	Q9H9D4	Y2H	15231747
Intra	EXOSC2	Q13868	EXOSC4	Homo sapiens	Q9NPD3	Anti Tag CoIP	26496610
Intra	EXOSC2	Q13868	EXOSC4	Homo sapiens	Q9NPD3	Anti Tag CoIP	33961781
Intra	EXOSC2	Q13868	EXOSC4	Homo sapiens	Q9NPD3	Density Sedimentation	17545563
Intra	EXOSC2	Q13868	EXOSC4	Homo sapiens	Q9NPD3	TAP	11719186
Intra	EXOSC2	Q13868	EXOSC4	Homo sapiens	Q9NPD3	Y2H	12419256
Intra	EXOSC2	Q13868	EXOSC7	Homo sapiens	Q15024	TAP	11719186
Intra	EXOSC2	Q13868	EXOSC7	Homo sapiens	Q15024	Y2H	15231747
Intra	EXOSC2	Q13868	EXOSC7	Homo sapiens	Q15024	Anti Tag CoIP	33961781
Intra	EXOSC2	Q13868	EXOSC7	Homo sapiens	Q15024	Anti Tag CoIP	26496610
Intra	EXOSC2	Q13868	EXOSC7	Homo sapiens	Q15024	Y2H	12419256
Intra	EXOSC2	Q13868	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	21255825
Intra	EXOSC2	Q13868	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	33961781
Intra	EXOSC2	Q13868	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	26496610
Intra	EXOSC2	Q13868	EXOSC3	Homo sapiens	Q9NQT5	TAP	11719186
Intra	EXOSC2	Q13868	EXOSC3	Homo sapiens	Q9NQT5	Density Sedimentation	17545563
Intra	EXOSC2	Q13868	MPHOSPH6	Homo sapiens	Q99547	Anti Bait CoIP	16396833
Intra	EXOSC2	Q13868	MPHOSPH6	Homo sapiens	Q99547	GMS	16396833
Intra	EXOSC2	Q13868	MPHOSPH6	Homo sapiens	Q99547	TAP	11719186
Intra	EXOSC2	Q13868	DIS3L	Homo sapiens	Q8TF46-1	Anti Tag CoIP	20531389

Cross: Cross-species interaction Intra: Intraspecies interaction

EXOSC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82141	RRP4 Antibody (YA1886)	WB	Human, Mouse, Rat
HY-P82141A	RRP4 Antibody (YA1886)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies	Retinitis Pigmentosa-Hearing Loss-Premature Aging-Short Stature-Facial Dysmorphism Syndrome SHRF Retinitis Pigmentosa-Deafness-Premature Aging-Short Stature-Facial Dysmorphism Syndrome
Pontocerebellar Hypoplasia, Type 1b	Pontocerebellar Hypoplasia Type 1b PCH1B Pontocerebellar Hypoplasia 1b Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia, Type 1c	PCH1C Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia Pontocerebellar Hypoplasia Type 1c Pontocerebellar Hypoplasia 1c Doid:0112334 Hypoplasia, Pontocerebellar, Type 1c
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1d	PCH1D Pontocerebellar Hypoplasia Type 1d Pontocerebellar Hypoplasia 1d Doid:0112323 Hypoplasia, Pontocerebellar, Type 1d
Trichohepatoenteric Syndrome 2	THES2
Telangiectatic Osteogenic Sarcoma	Telangiectatic Osteosarcoma
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract	Pharc Syndrome PHARC Polyneyropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract Polyneuropathy-Hearing Loss-Ataxia-Retinitis Pigmentosa-Cataract Syndrome Peripheral Neuropathy, Fiskerstrand Type Polyneuropathy-Deafness-Ataxia-Retinitis Pigmentosa-Cataract Syndrome Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, Cataract
Brachydactyly
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04598	EXOSC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EXOSC2	VGNC	VGNC:62007
Canis familiaris	EXOSC2	VGNC	VGNC:40523
Mus musculus	EXOSC2	MGD	MGI:2385133
Bos taurus	EXOSC2	VGNC	VGNC:28657
Macaca mulatta	EXOSC2	VGNC	VGNC:72287
Rattus norvegicus	EXOSC2	RGD	RGD:1306573
Others	EXOSC2	NCBI