MLKL-IN-5
MLKL-IN-5 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with a KD of < 10 nM. MLKL-IN-5 exhibits selectivity for RIP3 and RIP1, with KD values of 1-30 μM and > 30 μM, respectively. MLKL-IN-5 mediates necroptosis.
For research use only. We do not sell to patients.
- CAS No.: 2755872-58-1
- Formula: C18H20N6O4S
- Molecular Weight:416.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MLKL-IN-5 (Example 107) mediates necroptosis, a regulated caspase-independent cell death pathway with morphological features similar to necrosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2755872-58-1
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Molecular Weight 416.45
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Formula C18H20N6O4S
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SMILES
O=C(C1=C(NC2=NC(OC)=CC=C2)NN=C1C3=CC=C(NS(=O)(CC)=O)C=C3)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLKL-IN-5 Related Classifications
HY-148767 Related Classifications
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