2755872-58-1
2755872-58-1
Chemical Structure
MLKL-IN-5
- CAS No.: 2755872-58-1
- Formula:C18H20N6O4S
- Molecular Weight:416.45
IUPAC Name: (1-methyl-1H-1,2,4-triazol-3-yl)methyl (S)-(4-((3-chloro-4-fluorophenyl)carbamoyl)-7-fluoro-2,3-dihydro-1H-inden-1-yl)carbamate
InChIKey: WDIDNHYFQQNOBU-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=NC(OC)=CC=C2)NN=C1C3=CC=C(NS(=O)(CC)=O)C=C3)N
Biological Activity: MLKL-IN-5 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with a KD of < 10 nM. MLKL-IN-5 exhibits selectivity for RIP3 and RIP1, with KD values of 1-30 μM and > 30 μM, respectively. MLKL-IN-5 mediates necroptosis[1].
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MLKL-IN-5 | MLKL-IN-5 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with a KD of < 10 nM. MLKL-IN-5 exhibits selectivity for RIP3 and RIP1, with KD values of 1-30 μM and > 30 μM, respectively. MLKL-IN-5 mediates necroptosis. | |||||||||||||||||||||
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References
Keywords
