1. Metabolic Enzyme/Protease
  2. Factor Xa
  3. Delparantag

Delparantag (Synonyms: PMX-60056)

Cat. No.: HY-105240
Handling Instructions

Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and low molecular weight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Delparantag Chemical Structure

Delparantag Chemical Structure

CAS No. : 872454-31-4

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Description

Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and low molecular weight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH[1][2].

In Vitro

Delparantag is designed to restore coagulation by specifically binding to the pentasaccharide and disrupting UFH and LMWH interaction with antithrombin[1].
In heparinized plasma, Delparantag (PMX-60056) is more potent on a gravimetric basis than protamine at neutralizing both anti-Xa and anti-IIa activities. Delparantag is able to completely neutralize heparin at an approximate 2:1 gravimetric ratio. The amount of residual anti-IIa and anti-Xa activity was significantly less with Delparantag at a concentration of 50 mg/mL. In plasma anticoagulated with enoxaparin, Delparantag produces a concentration-dependent neutralization of anti-Xa activity. The amount of anti-Xa activity remaining after supplementation of the neutralizing agent is significantly less with Delparantag at concentrations above 25 mg/mL[2].

In Vivo

Delparantag (PMX-60056; 0.5 mg/kg, 1.0 mg/kg, or 2.0 mg/kg; intravenous injection; once; male Sprague-Dawley rats) treatment neutralizes the antithrombotic, anticoagulant, and bleeding effects of heparins as effectively as protamine sulfate and may be slightly more efficacious against LMWHs[2].
Plasma half-life elimination of Delparantag is between 3 and 5 min[1].

Animal Model: Male Sprague-Dawley rats (250-275 g) injected with UFH or LMWH (2.0 mg/kg)[2]
Dosage: 0.5 mg/kg, 1.0 mg/kg, or 2.0 mg/kg
Administration: Intravenous injection; once
Result: Neutralizes the antithrombotic, anticoagulant, and bleeding effects of heparins as effectively as protamine sulfate and may be slightly more efficacious against LMWHs.
Molecular Weight

1126.31

Formula

C₅₆H₇₉N₁₃O₁₂

CAS No.

872454-31-4

Sequence

{Lys}{Oaa}{Lys}{Oaa}{Lys}{Oaa}{Lys}

Sequence Shortening

K-Oaa-K-Oaa-K-Oaa-K

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DelparantagPMX-60056PMX60056PMX 60056Factor XaFxaAnticoagulantsheparinsalicylamidereversingbleedingantithromboticpentasaccharideInhibitorinhibitorinhibit

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