872454-31-4
Chemical Structure
Delparantag
Synonym(s): PMX-60056
- CAS No.: 872454-31-4
- Formula:C56H79N13O12
- Molecular Weight:1126.31
IUPAC Name: N-((S)-6-amino-1-((3-(((S)-6-amino-1-((3-(((S)-6-amino-1-((3-carbamoyl-4-methoxyphenyl)amino)-1-oxohexan-2-yl)carbamoyl)-4-methoxyphenyl)amino)-1-oxohexan-2-yl)carbamoyl)-4-methoxyphenyl)amino)-1-oxohexan-2-yl)-5-((S)-2,6-diaminohexanamido)-2-methoxybenza
InChIKey: PWFIFNGOPQUNIT-ITMZJIMRSA-N
SMILES: O=C(C(C=C1NC([C@H](CCCCN)NC(C(C=C2NC([C@@H](N)CCCCN)=O)=C(C=C2)OC)=O)=O)=C(C=C1)OC)N[C@@H](CCCCN)C(NC(C=C3)=CC(C(N[C@@H](CCCCN)C(NC(C=C4)=CC(C(N)=O)=C4OC)=O)=O)=C3OC)=O
Biological Activity: Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and low molecular weight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH[1][2].
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Delparantag | Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and low molecular weight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH. | |||||||||||||||||||||
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- [1]. Mahan CE. A 1-year drug utilization evaluation of protamine in hospitalized patients to identify possible future roles of heparin and low molecular weight heparin reversal agents. J Thromb Thrombolysis. 2014 Apr;37(3):271-8. [Content Brief]
- [2]. Kuziej J, et al. In vivo neutralization of unfractionated heparin and low-molecular-weight heparin by a novel salicylamide derivative. Clin Appl Thromb Hemost. 2010 Aug;16(4):377-86. [Content Brief]
Keywords
