Dexamethasone fluorescein

Dexamethasone fluorescein (10^-4 M; 6 h) exhibits a steady-state permeability constant (K_trans) of 1.64 × 10^-6 cm/sec in human scleral sections, which is significantly lower than the permeability of more hydrophilic compounds fluorescein and methotrexate-fluorescein^[1].
Dexamethasone fluorescein (100 μM; 10 hr) exhibits steady, gradual release from a fibrin sealant depot over 10 hours, with 4.0% of the initial amount released by the end of the period^[3].
Dexamethasone fluorescein (100 μM; 24 hr) delivered via fibrin sealant shows sustained transscleral diffusion across excised human scleral sections over 24 hours, with 1% of the initial amount diffused, an apparent scleral permeability of 1.58×10^-7 cm/s, and minimal tissue uptake of 3%^[3].
Dexamethasone fluorescein (1.0×10^-4 M; 24 hr) delivered in balanced salt solution (BSS) shows rapid transscleral diffusion across excised human scleral sections over 24 hours, with 18% of the initial amount diffused, an apparent scleral permeability of 2.57×10^-6 cm²/s, and substantial tissue uptake of 23%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.