216854-76-1
Chemical Structure
Dexamethasone fluorescein
- CAS No.: 216854-76-1
- Formula:C45H45FN2O9S2
- Molecular Weight:840.98
InChIKey: PNTRGJOSCFDTFY-WWNSBQJHSA-N
SMILES: O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(NC(NCCSCC([C@@]6([C@@]7([C@@]([C@@]8([H])[C@]([C@H](C7)O)([C@@]9(C(CC8)=CC(C=C9)=O)C)F)([H])C[C@H]6C)C)O)=O)=S)C=C51
Biological Activity: Dexamethasone fluorescein is a fluorescently labeled steroid conjugate that binds to glucocorticoid receptors. Dexamethasone fluorescein binds to glucocorticoid receptors. Dexamethasone fluorescein serves as a marker for evaluating the delivery of drugs via subconjunctival injection and intratympanic administration. Sustained transscleral diffusion is achieved when Dexamethasone fluorescein is delivered via fibrin sealant. Dexamethasone fluorescein can be used to investigate the binding and localization of glucocorticoid receptors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Dexamethasone fluorescein | Dexamethasone fluorescein is a fluorescently labeled steroid conjugate that binds to glucocorticoid receptors. Dexamethasone fluorescein binds to glucocorticoid receptors. Dexamethasone fluorescein serves as a marker for evaluating the delivery of drugs via subconjunctival injection and intratympanic administration. Sustained transscleral diffusion is achieved when Dexamethasone fluorescein is delivered via fibrin sealant. Dexamethasone fluorescein can be used to investigate the binding and localization of glucocorticoid receptors. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Cruysberg LP, et al. In vitro human scleral permeability of fluorescein, dexamethasone-fluorescein, methotrexate-fluorescein and rhodamine 6G and the use of a coated coil as a new drug delivery system. J Ocul Pharmacol Ther. 2002 Dec;18(6):559-69. [Content Brief]
- [2]. Li W, et al. Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2018 Jun;39(5):639-647. [Content Brief]
- [3]. Cruysberg LP, et al. In vitro sustained human transscleral drug delivery of fluorescein-labeled dexamethasone and methotrexate with fibrin sealant. Current eye research. 2005 Aug;30(8):653-60. [Content Brief]
Keywords
