Hmox1 - heme oxygenase 1 Gene

Also Known as Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24451

Summary

Enables several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and Phospholipase D activity. Involved in several processes, including intracellular signal transduction; negative regulation of apoptotic process; and regulation of gene expression. Located in several cellular components, including caveola; endoplasmic reticulum; and nucleolus. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); hepatic vascular disease (multiple); limb ischemia; and sciatic neuropathy. Biomarker of several diseases, including Sjogren's syndrome; artery disease (multiple); brain disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); Factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hmox1 Products (1)

mRNA Protein Name
NM_012580.2 NP_036712.1 heme oxygenase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate omega-hydroxylase activity IMP
IMP: Inferred from mutant phenotype
19889059 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
15516695 RGD
enables heme binding IDA
IDA: Inferred from direct assay
12044160 RGD
enables heme oxygenase (decyclizing) activity IDA
IDA: Inferred from direct assay
1575508 RGD
enables phospholipase D activity IDA
IDA: Inferred from direct assay
12511545 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15226268 RGD
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
12593860 RGD
involved in cellular response to nutrient IEP
IEP: Inferred from expression pattern
15531134 RGD
involved in heme catabolic process IDA
IDA: Inferred from direct assay
15226268 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12225959 RGD
involved in intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
11854317 RGD
involved in liver regeneration IMP
IMP: Inferred from mutant phenotype
24815159 RGD
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17234154 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16319139 RGD
involved in negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22093310 RGD
involved in negative regulation of mast cell cytokine production IDA
IDA: Inferred from direct assay
17234154 RGD
involved in negative regulation of mast cell degranulation IDA
IDA: Inferred from direct assay
17234154 RGD
involved in negative regulation of muscle cell apoptotic process IDA
IDA: Inferred from direct assay
12396617 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19177228 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19885007 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22709785 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20925964 RGD
involved in regulation of blood pressure IDA
IDA: Inferred from direct assay
12215473 RGD
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17430897 RGD
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
19889059 RGD
involved in response to arachidonate IMP
IMP: Inferred from mutant phenotype
19889059 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
15734876 RGD
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
17430897 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
14970910 RGD
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
12114196 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
17020887 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
29091898 RGD
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
12511545 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
15226268 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
3865203 RGD
located in nucleus IDA
IDA: Inferred from direct assay
17430897 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heme oxygenase 1

  • heme oxygenase (decycling) 1

  • heme oxygenase (decyclizing) 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-167874 ASP-8731 Inhibitor 98.42% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0643 Carnosol 99.90% Unkown
HY-124529 Lunularin Inhibitor 99.87% Unkown
HY-124815 CP-312 Inducer 99.18% Unkown
HY-RS06249 HMOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3001 Isolinderalactone 98.79% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-RS16718 Hmox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121523 MIND4-17 Activator 99.05% Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-160906 Glutathione trisulfide / Unkown
HY-RS23153 Hmox1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown
HY-170968 EGFR-IN-150 Inhibitor / Unkown
HY-175806 CS47 / Unkown
HY-183692 FXR agonist 18 / Unkown
HY-184288 Nrf-2/HMOX-1-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmox1 NCBI NCBI:3162
Mus musculus Hmox1 NCBI NCBI:15368