Hmox1 - heme oxygenase 1 Gene

Also Known as HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15368

Summary

Predicted to enable several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and protein homodimerization activity. Acts upstream of or within several processes, including cellular response to cisplatin; cellular response to metal ion; and regulation of macroautophagy. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); Factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hmox1 Products (1)

mRNA Protein Name
NM_010442.2 NP_034572.1 heme oxygenase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32973183 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to arsenic-containing substance IDA
IDA: Inferred from direct assay
12220541 MGI
acts upstream of or within cellular response to cadmium ion IDA
IDA: Inferred from direct assay
16183037 MGI
acts upstream of or within cellular response to cisplatin IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within heme catabolic process IGI
IGI: Inferred from genetic interaction
31571584 MGI
acts upstream of or within heme metabolic process IDA
IDA: Inferred from direct assay
16183037 MGI
acts upstream of macroautophagy IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within negative regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within positive regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20705711 MGI
acts upstream of or within positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
20705711 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IGI
IGI: Inferred from genetic interaction
31571584 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17430897 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heme oxygenase 1

  • P32 protein

  • heme oxygenase (decycling) 1

  • hemoxygenase

Recombinant Hmox1 Proteins

Cat. No. Product Name Accession Purity
HY-P700495 HO-1 Protein, Mouse (P. pastoris, His) P14901 (M1-M289) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-167874 ASP-8731 Inhibitor 98.42% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0643 Carnosol 99.90% Unkown
HY-124529 Lunularin Inhibitor 99.87% Unkown
HY-124815 CP-312 Inducer 99.18% Unkown
HY-RS06249 HMOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3001 Isolinderalactone 98.79% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-RS16718 Hmox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121523 MIND4-17 Activator 99.05% Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-160906 Glutathione trisulfide / Unkown
HY-RS23153 Hmox1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown
HY-170968 EGFR-IN-150 Inhibitor / Unkown
HY-175806 CS47 / Unkown
HY-183692 FXR agonist 18 / Unkown
HY-184288 Nrf-2/HMOX-1-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmox1 NCBI NCBI:3162