HMOX1 - heme oxygenase 1 Gene

Also Known as HO-1; HSP32; HMOX1D; bK286B10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3162

About HMOX1

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,381,096-35,394,207 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 1 paralogue and is associated with 4 phenotypes. Broad expression in spleen (RPKM 208.2), ovary (RPKM 68.8) and 17 other tissues.

Summary

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

HMOX1 Products (1)

mRNA	Protein	Name
NM_002133.3	NP_002124.1	heme oxygenase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heme binding	IDA IDA: Inferred from direct assay	17915953	GOA
enables heme oxygenase (decyclizing) activity	IDA IDA: Inferred from direct assay	7703255	GOA
enables heme oxygenase (decyclizing) activity	IMP IMP: Inferred from mutant phenotype	11121422	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19556236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19556236	GOA
enables structural molecule activity	IMP IMP: Inferred from mutant phenotype	19556236	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	21597468	GOA
involved in erythrocyte homeostasis	IMP IMP: Inferred from mutant phenotype	9884342	GOA
involved in heme catabolic process	IDA IDA: Inferred from direct assay	17915953	GOA
involved in heme oxidation	IDA IDA: Inferred from direct assay	17915953	GOA
involved in intracellular iron ion homeostasis	IDA IDA: Inferred from direct assay	17915953	GOA
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	22989377	GOA
involved in multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	9884342	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	18202225	GOA
involved in negative regulation of ferroptosis	IMP IMP: Inferred from mutant phenotype	26403645	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	17600318	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	21788589	GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	24844779	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	24844779	GOA
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	17600318	GOA
involved in response to nicotine	IDA IDA: Inferred from direct assay	18205746	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	9884342	GOA
involved in wound healing involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	9884342	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19556236	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	22419571	GOA
located in endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	19556236	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22503972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMOX1 Protein Structure

Heme_oxygenase

0
100
200
288 a.a.

Protein Preferred Names	Protein Names
heme oxygenase 1	heat shock protein, 32-kD

HMOX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HMOX1	P09601	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	HMOX1	P09601	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	HMOX1	P09601	ELOVL5	Homo sapiens	Q9NYP7	Validated Y2H	32296183
Intra	HMOX1	P09601	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
Intra	HMOX1	P09601	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	HMOX1	P09601	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	HMOX1	P09601	ELOVL6	Homo sapiens	Q9H5J4	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	ELOVL6	Homo sapiens	Q9H5J4	Validated Y2H	32296183
Intra	HMOX1	P09601	ELOVL6	Homo sapiens	Q9H5J4	Y2H Array	32296183
Intra	HMOX1	P09601	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	HMOX1	P09601	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	HMOX1	P09601	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	HMOX1	P09601	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	HMOX1	P09601	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	HMOX1	P09601	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	HMOX1	P09601	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	CRB3	Homo sapiens	Q9BUF7-2	Validated Y2H	32296183
Intra	HMOX1	P09601	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	HMOX1	P09601	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	HMOX1	P09601	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	HMOX1	P09601	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	HMOX1	P09601	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	HMOX1	P09601	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	HMOX1	P09601	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	HMOX1	P09601	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	HMOX1	P09601	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	HMOX1	P09601	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	HMOX1	P09601	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Cross	HMOX1	P09601	ap3a_sars2	SARS-CoV-2	P0DTC3	Y2H Array	36217030
Intra	HMOX1	P09601	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
Intra	HMOX1	P09601	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
Intra	HMOX1	P09601	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	HMOX1	P09601	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	HMOX1	P09601	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	HMOX1	P09601	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	HMOX1	P09601	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	HMOX1	P09601	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	STX1A	Homo sapiens	Q16623	Complementation	32296183
Intra	HMOX1	P09601	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	HMOX1	P09601	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	HMOX1	P09601	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	HMOX1	P09601	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	HMOX1	P09601	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	HMOX1	P09601	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	HMOX1	P09601	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	HMOX1	P09601	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	HMOX1	P09601	CYBRD1	Homo sapiens	Q53TN4	Validated Y2H	32296183
Intra	HMOX1	P09601	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	HMOX1	P09601	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	HMOX1	P09601	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	HMOX1	P09601	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	HMOX1	P09601	CYB561	Homo sapiens	P49447	Validated Y2H	32296183
Intra	HMOX1	P09601	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	HMOX1	P09601	MSMO1	Homo sapiens	Q15800	Validated Y2H	32296183
Intra	HMOX1	P09601	MSMO1	Homo sapiens	Q15800	Y2H Array	32296183
Intra	HMOX1	P09601	MSMO1	Homo sapiens	Q15800	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HMOX1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70276	HO-1 Protein, Human	P09601 (M1-T261)	≥ 95%, as determined by reducing SDS-PAGE.

HMOX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80499	Heme Oxygenase 1 Antibody (YA389)	WB, IHC-P, IP, FC	Human
HY-P84030	Heme Oxygenase 1 Antibody (YA3727)	IHC-P, FC, ELISA	Human
HY-P84030A	Heme Oxygenase 1 Antibody (YA3727)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85707	Heme Oxygenase 1 Antibody (YA5399)	IHC-P, WB, ICC/IF	Human, Mouse, Rat
HY-P86395	Heme Oxygenase 1 Antibody (YA6087)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Heme Oxygenase 1 Deficiency	HMOX1D Heme Oxygenase-1 Deficiency Ho-1 Deficiency
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Hepatopulmonary Syndrome
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Neonatal Jaundice	Neonatal Hyperbilirubinemia Neonatal Icterus Jaundice Neonatal Jaundice, Neonatal Hyperbilirubinemia, Neonatal
Ischemia	Acute Coronary Syndrome
Acute Chest Syndrome	Acute Chest Syndrome In Sickle Cell Disease
Pulmonary Emphysema
Arteriosclerosis	Arteriosclerotic Vascular Disease
Protoporphyria, Erythropoietic, 1	Erythropoietic Protoporphyria Epp Ferrochelatase Deficiency Protoporphyria, Erythropoietic Erythrohepatic Protoporphyria Heme Synthetase Deficiency Autosomal Erythropoietic Protoporphyria EPP1 Protoporphyria Protoporphyria Erythropoietic
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Siderosis	Pulmonary Siderosis Deposition Of Iron Arc-Welders' Disease Arc-Welders' Lung Arc-Welders' Nodulation Arc-Welders' Pneumoconiosis Iron Oxide Lung Iron Pneumoconiosis Pneumoconiosis Siderotico Siderotic Lung Disease Steel Grinders' Disease Welders' Lung Welders' Siderosis Lung Fibrosis With Siderosis
Acute Porphyria	Porphyrias, Hepatic Hepatic Porphyria Porphyria Hepatic Acute Intermittent Porphyria
Porphyria, Acute Intermittent	Acute Intermittent Porphyria Porphobilinogen Deaminase Deficiency Pbgd Deficiency AIP Porphyria, Swedish Type Uroporphyrinogen Synthase Deficiency Ups Deficiency Porphyria, Acute Intermittent, Nonerythroid Variant Hydroxymethylbilane Synthase Deficiency Aip - Acute Intermittent Porphyria Porphyria Intermittent Acute Pyrroloporphyria Hmbs Deficiency Porphyria Acute Intermittent
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Mycobacterium Marinum	Mycobacterium Marinum Infection Fish Tank Granuloma M. Marinum
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Porphyria	Hematoporphyria Porphyrias Disorder Of Porphyrin And Hem Metabolism Disorder Of Porphyrin Metabolism Porphyrinopathy Porphyrin Disorder Disorder Of Porphyrin And Heme Metabolism Disorders Of Porphyrin Metabolism
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Silicosis	Silicotuberculosis Acute Silicosis Chronic Silicosis Pneumoconiosis Due To Silicates Silica Pneumoconiosis Silicotic Fibrosis Of Lung Accelerated Silicosis Experimental Silicosis
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Arthus Reaction	Arthus Phenomenon Arthus Type Urticaria
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Cataract 38	CTRCT38 Catc5 Autosomal Recessive Congenital Cataract 5 Cataract, Autosomal Recessive Congenital 5 Cataract 38, Autosomal Recessive Cataract, Type 38
Diabetic Encephalopathy
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Central Nervous System Disease	Cns Disorder CNS Cns Diseases Central Nervous System Diseases
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Lung Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Lung
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Retinal Ischemia
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Diabetes Mellitus	Diabetes
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Functional Gastric Disease
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Cerebral Artery Occlusion
Acute Kidney Tubular Necrosis	Acute Tubular Necrosis Acute Renal Failure With Tubular Necrosis Acute Tubule Necrosis Acute Renal Failure With Lesion Of Tubular Necrosis Atn - Acute Tubular Necrosis Tubular Necrosis Acute Kidney Tubular Necrosis, Acute Acute Renal Tubular Necrosis Acute Tubular Nephrosis Ischaemic Acute Tubular Necrosis Ischaemic Tubular Necrosis Kidney Tubular Necrosis Lower Nephron Nephrosis Necrotising Renal Oedema Renal Tubular Necrosis Toxic Tubular Necrosis Tubular Kidney Necrosis Tubular Necrosis Nos Tubular Nephrosis
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Diamond-Blackfan Anemia 1	Aase Syndrome DBA1 Erythrogenesis Imperfecta Aase-Smith Syndrome Ii Dba Blackfan-Diamond Syndrome Bds Anemia, Congenital Hypoplastic, Of Blackfan And Diamond Anemia, Congenital Erythroid Hypoplastic Red Cell Aplasia, Pure, Hereditary Aregenerative Anemia, Chronic Congenital Rps19-Related Diamond-Blackfan Anemia Chronic Congenital Aregenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Pure Hereditary Red Cell Aplasia Anemia, Diamond-Blackfan, Type 1 Anemia, Diamond-Blackfan Aase Smith Syndrome 2 Familial Hypoplastic Anaemia With Malformations Constitutional Pure Red Cell Aplasia
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Esophagus Carcinoma In Situ	Carcinoma In Situ Of Esophagus Carcinoma In Situ Of Oesophagus Oesophagus Carcinoma In Situ Severe Esophageal Dysplasia Stage 0 Carcinoma Of The Esophagus Stage 0 Carcinoma Of The Oesophagus Severe Oesophageal Dysplasia
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-167874	ASP-8731	Inhibitor	98.42%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0643	Carnosol		99.90%	Unkown
HY-124529	Lunularin	Inhibitor	99.87%	Unkown
HY-124815	CP-312	Inducer	99.18%	Unkown
HY-RS06249	HMOX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3001	Isolinderalactone		98.79%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-RS16718	Hmox1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121523	MIND4-17	Activator	99.05%	Unkown
HY-173444	HDAC11-IN-3		99.70%	Unkown
HY-160906	Glutathione trisulfide		/	Unkown
HY-RS23153	Hmox1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-170968	EGFR-IN-150	Inhibitor	/	Unkown
HY-175806	CS47		/	Unkown
HY-183692	FXR agonist 18		/	Unkown
HY-184288	Nrf-2/HMOX-1-IN-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HMOX1	RGD	RGD:2806
Bos taurus	HMOX1	VGNC	VGNC:29885
Macaca mulatta	HMOX1	VGNC	VGNC:73488
Mus musculus	HMOX1	MGD	MGI:96163
Canis familiaris	HMOX1	VGNC	VGNC:41719
Others	HMOX1	NCBI