SNX10 - sorting nexin 10 Gene

Also Known as OPTB8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29887

About SNX10

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,291,862-26,374,383 (from NCBI)

This gene has 27 transcripts (splice variants), 278 orthologues, 15 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 20.5), appendix (RPKM 13.4) and 19 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

SNX10 Products (8)

mRNA Protein Name
NM_001199835.1 NP_001186764.1 sorting nexin-10 isoform 1
NM_001199837.3 NP_001186766.1 sorting nexin-10 isoform 2
NM_001199838.2 NP_001186767.1 sorting nexin-10 isoform 3
NM_001318198.1 NP_001305127.1 sorting nexin-10 isoform 4
NM_001318199.3 NP_001305128.1 sorting nexin-10 isoform 1
NM_001362753.1 NP_001349682.1 sorting nexin-10 isoform 4
NM_001362754.1 NP_001349683.1 sorting nexin-10 isoform 4
NM_013322.3 NP_037454.2 sorting nexin-10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol binding IMP
IMP: Inferred from mutant phenotype
17012226 GOA
enables ATPase binding IPI
IPI: Inferred from physical interaction
21844891 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
21844891 GOA
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
17012226 GOA
involved in protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
21844891 GOA
involved in protein localization to cilium IMP
IMP: Inferred from mutant phenotype
21844891 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with centrosome IDA
IDA: Inferred from direct assay
21844891 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22174188 GOA
located in extrinsic component of endosome membrane IDA
IDA: Inferred from direct assay
17012226 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22174188 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX10 Protein Structure

PX

PX: PX domain (12 - 123)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

sorting nexin-10

SNX10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNX10 Q9Y5X0 PRKCA Homo sapiens P17252
Validated Y2H
32814053
Intra
SNX10 Q9Y5X0 PRKCA Homo sapiens P17252
Y2H Array
32814053
Intra
SNX10 Q9Y5X0 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
SNX10 Q9Y5X0 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
SNX10 Q9Y5X0 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
SNX10 Q9Y5X0 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
SNX10 Q9Y5X0 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
SNX10 Q9Y5X0 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
SNX10 Q9Y5X0 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
SNX10 Q9Y5X0 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
SNX10 Q9Y5X0 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
SNX10 Q9Y5X0 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
Intra
SNX10 Q9Y5X0 RABAC1 Homo sapiens Q9UI14
Y2H Array
32296183
Intra
SNX10 Q9Y5X0 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
Intra
SNX10 Q9Y5X0 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
Intra
SNX10 Q9Y5X0 ARL6IP1 Homo sapiens Q15041
Validated Y2H
25416956
Intra
SNX10 Q9Y5X0 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
SNX10 Q9Y5X0 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
SNX10 Q9Y5X0 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Osteopetrosis, Autosomal Recessive 8

  • Autosomal Recessive Osteopetrosis 8

  • OPTB8

  • Osteopetrosis, Autosomal Recessive, Type 8
Autosomal Recessive Malignant Osteopetrosis

  • Infantile Malignant Osteopetrosis
Osteopetrosis

  • Marble Bone Disease

  • Albers-Schonberg Disease

  • Osteopetroses

  • Marble Bones

  • Osteopetrosis And Related Disorders

  • Congenital Osteopetrosis

  • Marble Bone

  • Albers-Schoenberg Disease

  • Albers-Schonberg Osteopetrosis

  • Osteosclerosis Fragilis

  • Ivory Bones
Osteopetrosis, Autosomal Recessive 2

  • OPTB2

  • Autosomal Recessive Osteopetrosis 2

  • Osteopetrosis, Mild Autosomal Recessive Form

  • Osteoclast-Poor Osteopetrosis

  • Osteopetrosis, Osteoclast-Poor

  • Mild Autosomal Recessive Form Osteopetrosis

  • Osteopetrosis Autosomal Recessive 2

  • Autosomal Recessive Osteopetrosis Type 2

  • Osteopetrosis Osteoclast-Poor

  • Osteopetrosis, Autosomal Recessive, Type 2
Pycnodysostosis

  • Pyknodysostosis

  • PKND

  • Pycd

  • Toulouse-Lautrec Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160477 DC-SX029 Inhibitor 98.07% Unkown
HY-RS13523 SNX10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20105 Snx10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26609 Snx10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SNX10 VGNC VGNC:77705
Bos taurus SNX10 VGNC VGNC:35091
Mus musculus SNX10 MGD MGI:1919232
Felis catus SNX10 VGNC VGNC:102706
Rattus norvegicus SNX10 RGD RGD:1305782
Canis familiaris SNX10 VGNC VGNC:46620
Others SNX10 NCBI