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HPN - hepsin Gene

Also Known as TMPRSS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3249

About HPN

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:35,040,506-35,066,573 (from NCBI)

This gene has 11 transcripts (splice variants), 194 orthologues and 17 paralogues. Biased expression in liver (RPKM 53.7), kidney (RPKM 49.5) and 5 other tissues.

Summary

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate Cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

HPN Products (4)

mRNA	Protein	Name
NM_001375441.3	NP_001362370.1	serine protease hepsin precursor
NM_001384133.1	NP_001371062.1	serine protease hepsin precursor
NM_002151.5	NP_002142.1	serine protease hepsin precursor
NM_182983.5	NP_892028.1	serine protease hepsin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	16908524	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15614436	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	16908524	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	19911255	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in basement membrane disassembly	IDA IDA: Inferred from direct assay	16908524	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15614436	GOA
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	19843851	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	19843851	GOA
involved in positive regulation by host of viral transcription	IDA IDA: Inferred from direct assay	15614436	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	8346233	GOA
involved in positive regulation of hepatocyte proliferation	IDA IDA: Inferred from direct assay	15614436	GOA
involved in positive regulation of plasminogen activation	IDA IDA: Inferred from direct assay	16908524	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	16908524	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	8346233	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	8346233	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17918732	GOA
located in membrane	IDA IDA: Inferred from direct assay	19843851	GOA
colocalizes with nuclear membrane	IDA IDA: Inferred from direct assay	15614436	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	1885621	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPN Protein Structure

Hepsin-SRCR

Trypsin

0
100
200
300
417 a.a.

Protein Preferred Names	Protein Names
serine protease hepsin	testicular tissue protein Li 85

HPN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HPN	P05981	SFTPC	Homo sapiens	P11686	Validated Y2H	32296183
Intra	HPN	P05981	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HPN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77693	TMPRSS1/HPN Protein, Human (HEK293, His)	P05981 (R45-L417)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Prostatic Hyperplasia, Benign	Benign Prostatic Hyperplasia BPH Prostatic Hyperplasia
Deafness, Autosomal Recessive 39	DFNB39 Autosomal Recessive Nonsyndromic Deafness 39 Autosomal Recessive Deafness 39 Deafness, Autosomal Recessive, 39 Congenital Neurosensory Deafness Autosomal Recessive 39 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39 Deafness, Autosomal Recessive, Type 39
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2087	Glycerol phenylbutyrate		99.81%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-135366	HPN-01	Inhibitor	98.61%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990920	Gocatamig	Inhibitor	≥99.0%	Phase 2
HY-P991088	HPN536	Inhibitor	99.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06342	HPN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18736	Hpn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25223	Hpn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990939	Podentamig	Inhibitor	/	Unkown
HY-P992370	HPN601	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HPN	VGNC	VGNC:67639
Bos taurus	HPN	VGNC	VGNC:29942
Mus musculus	HPN	MGD	MGI:1196620
Canis familiaris	HPN	VGNC	VGNC:41772
Rattus norvegicus	HPN	RGD	RGD:61982
Macaca mulatta	HPN	VGNC	VGNC:73513
Others	HPN	NCBI