SCAF1 - SR-related CTD associated factor 1 Gene

Also Known as SRA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58506

About SCAF1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,640,465-49,658,642 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 11.1), brain (RPKM 11.1) and 25 other tissues.

Summary

Enables RNA polymerase II C-terminal domain binding activity. Predicted to be involved in RNA splicing; mRNA processing; and transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SCAF1 Products (1)

mRNA	Protein	Name
NM_021228.3	NP_067051.2	splicing factor, arginine/serine-rich 19

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II C-terminal domain binding	IPI IPI: Inferred from physical interaction	15992770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
splicing factor, arginine/serine-rich 19	SCAF

SCAF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCAF1	Q9H7N4	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	MTSS2	Homo sapiens	Q765P7	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	MTSS2	Homo sapiens	Q765P7	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	SCAF1	Q9H7N4	CIB1	Homo sapiens	Q99828	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	RTN4IP1	Homo sapiens	Q8WWV3	Y2H Array	32296183
Intra	SCAF1	Q9H7N4	RTN4IP1	Homo sapiens	Q8WWV3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive 3	SCAR3 Scabd Autosomal Recessive Spinocerebellar Ataxia Type 3 Autosomal Recessive Spinocerebellar Ataxia-Blindness-Deafness Syndrome Autosomal Recessive Spinocerebellar Ataxia-Blindness-Hearing Loss Syndrome Spinocerebellar Ataxia With Blindness And Deafness Autosomal Recessive Spinocerebellar Ataxia 3 Spinocerebellar Ataxia Autosomal Recessive 3 Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness Autosomal Recessive Cerebellar Ataxia-Blindness-Deafness Syndrome
Pituitary Adenoma 3, Multiple Types	PITA3 Pituitary Adenoma 3, Multiple Types, Somatic Pituitary Adenoma 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03075	COX7A2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12474	SCAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SCAF1	MGD	MGI:2141980
Bos taurus	SCAF1	VGNC	VGNC:34313
Macaca mulatta	SCAF1	VGNC	VGNC:77137
Canis familiaris	SCAF1	VGNC	VGNC:45888
Rattus norvegicus	SCAF1	RGD	RGD:708405
Others	SCAF1	NCBI